Publications by Alec Droujinine

Publications by authors named "Alec Droujinine"

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Fumarate Upregulates Surface Expression of ULBP2/ULBP5 by Scavenging Glutathione Antioxidant Capacity.

Rikke Illum Høgh Alec Droujinine Sofie Hedlund Møller Stine Dam Jepsen Maiken Mellergaard

J Immunol

April 2020

Fumarate is a tricarboxylic acid cycle metabolite whose intracellular accumulation is linked to inflammatory signaling and development of cancer. In this study, we demonstrate that endogenous fumarate accumulation upregulates surface expression of the immune stimulatory NK group 2, member D (NKG2D) ligands ULBP2 and ULBP5. In agreement with this, accumulation of fumarate by the therapeutic drug dimethyl fumarate (DMF) also promotes ULBP2/5 surface expression.

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