A 10-18:1 enriched fraction from beef fed a barley grain-based diet induces lipogenic gene expression and reduces viability of HepG2 cells.

Beef fat is a natural source of fatty acids, and is typically enriched with either 10-18:1 or 11-18:1. Little is known about the bioactivity of individual -18:1 isomers, and the present study compared the effects of 9-18:1, ()9-18:1 and -18:1 fractions isolated from beef fat enriched with either 10-18:1 (HT10) or 11-18:1 (HT11). All 18:1 isomers resulted in reduced human liver (HepG2) cell viability relative to control.