Publications by authors named "Alec Allee-Munoz"
Article Synopsis
- The study explores why parents in minority communities are hesitant about the HPV vaccine, pointing out issues like medical mistrust and negative vaccine information.
- Approximately 20% of surveyed parents showed high hesitancy towards the vaccine, with over half concerned about its safety and side effects.
- The findings suggest a need for community-specific strategies to boost vaccine confidence among these groups to improve overall vaccination rates for adolescents.
Rhoptry neck protein 2 (RON2) binds to the hydrophobic groove of apical membrane antigen 1 (AMA1), an interaction essential for invasion of red blood cells (RBCs) by Plasmodium falciparum (Pf) parasites. Vaccination with AMA1 alone has been shown to be immunogenic, but unprotective even against homologous challenge in human trials. However, the AMA1-RON2L (L is referred to as the loop region of RON2 peptide) complex is a promising candidate, as preclinical studies with Freund's adjuvant have indicated complete protection against lethal challenge in mice and superior protection against virulent infection in Aotus monkeys.
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