Publications by authors named "Aleah DeSchmidt"
Article Synopsis
- Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease primarily affecting small bile ducts, with limited treatment options and a reliance on liver transplants in severe cases.
- Researchers studied T cell responses to a specific protein (PDC-E2) linked to PBC, focusing on a common genetic marker (HLA Class II DRB4∗01:01) found in many patients.
- They discovered unique T cell receptors (TCRs) that can target a new PDC-E2 epitope, leading to the development of engineered regulatory T cells (EngTreg) that could help suppress harmful immune responses in PBC patients, offering potential for new therapies.
Performing a small bowel anastomosis, or reconnecting small bowel segments, remains a core competency and critical step for the successful surgical management of numerous bowel and urinary conditions. As surgical education and technology moves toward improving patient outcomes through automation and increasing training opportunities, a detailed characterization of the interventional biomechanical properties of the human bowel is important. This is especially true due to the prevalence of anastomotic leakage as a frequent (3.
View Article and Find Full Text PDFAccurate human tissue biomechanical data represents a critical knowledge gap that will help facilitate the advancement of new medical devices, patient-specific predictive models, and training simulators. Tissues related to the human airway are a top priority, as airway medical procedures are common and critical. Placement of a surgical airway, though less common, is often done in an emergent (cricothyrotomy) or urgent (tracheotomy) fashion.
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