Surgical Anatomy of the Mesopancreas in Obese Patients: A Retrospective Study.

Introduction The mesopancreas is described as a triangle formed by the superior mesenteric vein, celiac axis (CA), and superior mesenteric artery (SMA). It is the most likely site of residual cancer and local recurrence after surgical resection, making it the key site of the current radical resection of pancreatic head cancer. The surgical anatomy of the mesopancreas triangle has not been studied in detail.

Non-Functioning Adrenocortical Carcinoma Presenting as Retroperitoneal Hemorrhage With Early Metastasis.

Adrenocortical cancer is a rare neoplasm with varied clinical presentation and overall poor outcome. This should be managed with timely intervention at highly specialized centers. Our aim is to report this rare case presentation of large non-functional adrenocortical cancer, complicated by spontaneous rupture while awaiting workup leading to life-threatening hemorrhage.

Automatic Segmentation of Calcification Areas in Digital Breast Images.

In this study, the authors hope to demonstrate that when mammography is combined with intelligent segmentation techniques, it can become more effective in diagnosing breast abnormalities and aiding in the early detection of breast cancer. In conjunction with intelligent segmentation techniques, mammography can be made more effective in diagnosing breast abnormalities and aiding in the early diagnosis of breast cancer, hence increasing its overall effectiveness. The methodology, which includes some concepts of digital imaging and machine learning techniques, will be described in the following section after a review of the literature on breast cancer (categories, prevention involving the environment and lifestyle, diagnosis, and tracking of the disease) has been completed (neural networks and random forests).

Hyperspectral Image Analysis of Colon Tissue and Deep Learning for Characterization of Health care.

Colon cancer is a disease characterized by the unusual and uncontrolled development of cells that are found in the large intestine. If the tumour extends to the lower part of the colon (rectum), the cancer may be colorectal. Medical imaging is the denomination of methods used to create visual representations of the human body for clinical analysis, such as diagnosing, monitoring, and treating medical conditions.

Discovery of Knowledge in the Incidence of a Type of Lung Cancer for Patients through Data Mining Models.

This paper presents the research results on the contribution of user-centered data mining based on the standard principles, focusing on the analysis of survival and mortality of lung cancer cases. Researchers used anonymized data from previously diagnosed instances in the health database to predict the condition of new patients who have not had their results yet. Medical professionals specializing in this field provided feedback on the usefulness of the new software, which was constructed using WEKA data mining tools and the Naive Bayes method.

Early Detection of Autism Spectrum Disorders (ASD) with the Help of Data Mining Tools.

Autism is a disorder of neurobiological origin that originates a different course in the development of verbal and nonverbal communication, social interactions, the flexibility of behavior, and interests. The results obtained offer relevant information to reflect on the practices currently used in assessing the development of children and the detection of ASD and suggest the need to strengthen the training of health professionals in aspects such as psychology and developmental disorders. This study, based on genuine and current facts, used data from 292 children with an autism spectrum disorder.

Assessing Deep Learning Techniques for the Recognition of Tropical Disease in Images from Parasitological Exams.

is one of the tropical diseases with the greatest epidemic reach in the world. One of the WHO guidelines is the prior and efficient diagnosis for mapping foci and applying the appropriate treatment of infected people. The current process for diagnosis still depends on an analysis of parasitological exams performed by a human being under a laboratory microscope.

Improved survival in children with HPS: Experience from two high volume liver transplant centers across continents.

Background: Severe HPS increases morbidity and mortality after LT in children. We reviewed the combined experience of LT for HPS in children from two LT centers in Europe and Asia.

Methods: All children with "proven" HPS as per ERS Task Force criteria (detailed in manuscript) who underwent LT were categorized into M (PaO ≥80 mmHg), Mo (PaO  = 60-79 mmHg), S (50-59 mmHg), and VS (PaO <50 mmHg) HPS, based on room air PaO .

Colonoscopy Quality and Adherence to Postpolypectomy Surveillance Guidelines in an Underinsured Clinic System.

Background: Delivery of high-quality colonoscopy and adherence to evidence-based surveillance guidelines is essential to a high-quality screening program, especially in safety net systems with limited resources. We sought to assess colonoscopy quality and ensure appropriate surveillance in a network of safety net practices.

Methods: We identified age-eligible patients ages 50-75 within a Federally Qualified Health Center (FQHC) clinic system with evidence of colonoscopy in preceding 10 years.

Iris-fixated phakic intraocular lens explantation.

Background/aims: To evaluate the visual outcomes and indication for surgery in a series of patients who underwent explantation of a phakic intraocular lens (PIOL).

Methods: A retrospective case series of patients who underwent PIOL explantation in our institution was performed. The indication for explantation and visual and refractive outcomes were examined.

Coronary artery fistula between the left anterior descending artery and pulmonary artery.

Coronary artery fistula is a rare anomalous connection between a coronary artery and a cardiac chamber or major vessel. Here we present the case of a 36-year-old woman who presented with sharp, substernal chest pain, dyspnea, and dizziness. A fistula between her left anterior descending artery and pulmonary trunk was found.

Navigating the Root of the Mesentery: A Guided Approach to an Artery-First Pancreatoduodenectomy.

In the standard technique of pancreatoduodenectomy (PD), the superior mesenteric artery (SMA) is approached following Kocher maneuver of the duodenum. Alternative approaches include SMA first with no touch approaches. The aim of this article is to report the preoperative planning for and operative techniques of a combined artery first with no touch technique (CTPD) for the performance of PD.

Outcome of long interval radiological surveillance of side branch pancreatic duct-involved intraductal papillary mucinous neoplasm in selected patients.

Introduction: Side branch IPMN (SB-IPMN) of the pancreas has a malignancy rate between 10 and 20%. We hypothesized that surveillance at longer intervals on selected patients with SB-IPMN might be indicated.

Methods: This is a retrospective study of prospectively collected data of 276 patients presenting from 2000 to 2010.

TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.

Organelle ion homeostasis within the endo-lysosomal system is critical for physiological functions. Two-pore channels (TPCs) are cation channels that reside in endo-lysosomal organelles, and overexpression results in endo-lysosomal trafficking defects. However, the impact of a lack of TPC expression on endo-lysosomal trafficking is unknown.

A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol.

Background: Laparoscopic pancreaticoduodenectomy (LPD) is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes, in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy (OPD).

Results of pancreatic surgery in the elderly: is age a barrier?

Background: By 2033, the number of people aged 85 years and over in the UK is projected to double, accounting for 5% of the total population. It is important to understand the surgical outcome after a pancreatic resection in the elderly to assist decision making.

Methods: Over a 9-year period (from January 2000 to August 2009), 428 consecutive patients who underwent a pancreatic resection were reviewed.

Cell carriage, delivery, and selective replication of an oncolytic virus in tumor in patients.

Oncolytic viruses, which preferentially lyse cancer cells and stimulate an antitumor immune response, represent a promising approach to the treatment of cancer. However, how they evade the antiviral immune response and their selective delivery to, and replication in, tumor over normal tissue has not been investigated in humans. Here, we treated patients with a single cycle of intravenous reovirus before planned surgery to resect colorectal cancer metastases in the liver.

Acceptable outcome after kidney transplantation using "expanded criteria donor" grafts.

Introduction: With the worldwide shortage of donors, extra lengths are ongoing to enlarge the donor pool. One means has been a greater use of "expanded criteria donor" (ECD) grafts. A major concern regarding ECD kidneys is poor long-term graft survival.

Correlation between postoperative infective complications and long-term outcomes after hepatic resection for colorectal liver metastasis.

Background: The impact of postoperative morbidity, and in particular infective complications on long-term outcomes, following hepatic resection for colorectal liver metastasis (CRLM) is not widely published.

Objective: To evaluate the effect of postoperative complications on disease recurrence and overall survival in patients undergoing hepatic resection for CRLM.

Methods: All patients undergoing hepatic resection for CRLM from January 1993 and March 2007 were identified, and postoperative complications analyzed.

Liver transplantation following donation after cardiac death: an analysis using matched pairs.

Grafts from donation after cardiac death (DCD) donors are used to increase the number of organs available for liver transplantation. There is concern that warm ischemia may impair graft function. We compared our DCD recipients with a case-matched group of donation after brain death (DBD) recipients.

Outcomes of kidney grafts refused by one or more centers and subsequently transplanted at a single United Kingdom center.

Introduction: The rate-limiting factor in kidney transplantation is the shortage of donor organs with resulting steady increase in patients on the transplant waiting list. In our center we have seen an increase in the use of kidneys refused as unsuitable by one or more centers in the United Kingdom (UK). This study was performed to analyze the outcomes of transplantation from kidneys refused by one or more centers and subsequently transplanted by our institution.

Outcomes in right liver lobe transplantation: a matched pair analysis.

Split liver transplantation (SLT) has proven to be an effective technique of increasing the donor pool and thereby reducing adult and paediatric waiting list mortality. There remains concern regarding complications in adult recipients. Here, we compare SLT with matched whole liver grafts.

Presentation and management of perirectal sepsis.

Perirectal sepsis is a potentially severe complication which may follow minor anorectal intervention and be slow to be diagnosed and treated. We report the presentation and outcome of three patients with perirectal sepsis of differing aetiologies. Awareness of the possible diagnosis, urgent investigation with cross-sectional imaging and immediate treatment with broad-spectrum antibiotics is vital.

The risk of gallbladder cancer from polyps in a large multiethnic series.

Background: The aim of this study is assess whether patients with Indian ethnic background are at an increased risk of developing gallbladder cancer (GBC) if they have been diagnosed with ultrasonic abnormalities of the gallbladder.

Methods: Between January 1998 and July 2006, 137,655 abdominal ultrasound examinations were performed in Leeds Teaching Hospitals NHS Trust. After the exclusion of repeat scans and those performed for renal or pelvic disease, 71,431 reports were included in this analysis.

The role of (99m)technetium-labelled hepato imino diacetic acid (HIDA) scan in the management of biliary pain.

Objective: To assess the outcome of laparoscopic cholecystectomy on the basis of an abnormal provocative (99m)technetium-labelled hepato imino diacetic acid (HIDA) scan for patients with typical biliary pain and normal trans-abdominal ultrasound (TUS) scan.

Patients And Methods: Prospective data were collected for 1201 consecutive patients with typical biliary symptoms. Patients who were found to have a normal TUS and upper GI endoscopy subsequently underwent cholescintigraphy (HIDA scan).