Ellagic acid and allopurinol decrease HO concentrations, epileptiform activity and astrogliosis after status epilepticus in the hippocampus of adult rats.

Status epilepticus (SE) can result in an overproduction of hydrogen peroxide (HO), which contributes to oxidative stress and brain injury during different phases of epileptogenesis and seizures. The purpose of this study was to evaluate the effects of ellagic acid and allopurinol administered after SE on HO concentrations, electrical activity and GFAP immunoreactivity in the hippocampus of rats evaluated on Day 18 after SE. HO levels were measured using an online technique with high temporal resolution and simultaneous electrical activity recording.