Differential inhibition of globus pallidus neurons by electrical or chemical stimulation of the striatum.

The reciprocal connections between the globus pallidus (GP) and other basal ganglia (BG) nuclei indicate that the GP plays a significant role in controlling the neuronal activity of the entire BG; in turn, the activity of GP neurons is controlled by several major inputs that involve the striatum. Here, we determined the relative contributions of the selective (chemical) or massive (electrical) activation of the striatal GABAergic transmission to the GP spiking activity. In vivo extracelullar single-unit recordings were performed in the GP of ketamine-anesthetized rats.

Stereospecific activity of two glutamate analogs.

Two glutamic acid analogs, (+)-(S)- and (-)-(R)-4-(2,2-diphenyl-1,3,2-oxazaborolidin-5-oxo)propionic acid ((+)-(S)- and (-)-(R)-Trujillon, respectively), were prepared. The stereospecific activity of their pharmacological properties was studied. The median convulsant dose (CD(50)) and median lethal dose (LD(50)) were analyzed in female Swiss Webster mice and their effects in vivo on unitary electrical activity in globus pallidus neurons were elucidated in male Wistar rats.