Factors Affecting Vancomycin Trough Concentration; a Population Pharmacokinetic Model in Non-Critical Care Saudi Patients.

Background And Objective: Vancomycin is commonly prescribed in treatment of methicillin-resistant Staphylococcus aureus infections. While, vancomycins' pharmacokinetic vary among older patients, there is a paucity of data regarding specific characteristics influencing pharmacokinetics in Saudi adult patients. This study aims to establish a population-pharmacokinetic (Pop-PK) model for vancomycin in patients admitted to medical wards, with the focus on identification of patient characteristics influencing vancomycin trough concentrations.

Awareness, Knowledge, Attitudes, and Practices of Diabetic Nephropathy Among the General Population in Hafr Al Batin, Saudi Arabia: A Cross-Sectional Study.

Background Diabetic nephropathy, a leading cause of end-stage renal disease (ESRD), plays a part in the critical healthcare burden globally, especially in Saudi Arabia, where the prevalence of diabetes cases is among the highest worldwide. This study aims to assess the awareness, knowledge, attitudes, and practices (A-KAP) in relation to diabetic nephropathy among the general population in Hafr Al Batin, Saudi Arabia. Methods A cross-sectional study was conducted between January and September 2024, involving 406 participants with a minimum age range of 18 years and older.

The prevalence of polypharmacy and hyper-polypharmacy among middle-aged vs older patients in Saudi Arabia: a cross-sectional study.

Introduction: Polypharmacy, the use of multiple medications, is a growing concern among middle-aged and older patients, posing potential risks and challenges in healthcare management.

Aim: This study aimed to identify the prevalence of polypharmacy and hyper-polypharmacy among populations of middle-aged vs older patients and identify its associated common comorbidities and prescribed medications in Qatif Central Hospital (QCH), Saudi Arabia.

Methods: Patients aged 40 years or older who presented to an outpatient medical care clinic at QCH, Saudi Arabia, between 1 January and 31 December 2021 were included, and their comorbidities, prescribed medications, and recent clinical laboratory test results were collected.

Safety and Efficacy of Direct Oral Anticoagulant in Addition to Antiplatelet Therapy After Acute Coronary Syndrome: A Systemic Review and Meta-analysis of 53,869 Patients.

Introduction: Significant progress has been made in the management of patients with acute coronary syndrome (ACS) during the past few decades. However, the role of direct oral anticoagulants (DOACs) in post-ACS prophylactic therapy remains unknown. This study aims to assess the efficacy and safety of DOACs plus antiplatelet treatment (APT) after ACS.

Monthly variations in acute coronary syndromes outcomes during the first year of the COVID-19 pandemic.

Background: Cardiovascular disease, particularly acute coronary syndromes (ACS), is the leading cause of death in the United States. Minor fluctuations in hospital admissions for different conditions, including ACS, can be seen throughout the year. This study focuses on the impact of admission month on outcomes of acute coronary syndromes during the first year of the COVID-19 pandemic.

Fracture Dislocation at the Level of C6-C7: A Case Report and Literature Review.

Fractures of the cervical spine can cause devastating long-term effects on patients. Spinal cord injuries can occur in up to 50% of cases in association with cervical spine fractures. Therefore, it is vital and of utmost importance to recognize cervical spine injuries early on to avoid the exacerbation of an existing injury and its detrimental effects on the patients.

A Glance at the Development and Patent Literature of Tecovirimat: The First-in-Class Therapy for Emerging Monkeypox Outbreak.

Monkeypox disease (MPX) is currently considered a global threat after COVID-19. European Medicines Agency (EMA) approved Tecovirimat in capsule dosage form (200 mg) as the first treatment for MPX in January 2022. This article highlights Tecovirimat's development and patent literature review and is believed to benefit the scientists working on developing MPX treatments.

Osseointegrated device placement with minimally invasive surgery: Experience and audiological outcome.

Objectives: To evaluate the clinical and audiological outcomes of percutaneous bone conduction device placement by minimally invasive Ponto surgery (MIPS).

Methods: This was a retrospective descriptive study of patients who underwent MIPS from March-November 2019 at King Abdullah Ear Specialist Center, Collage of Medicine, King Saud University, Riyadh, Saudi Arabia. We reviewed all the clinical data of patients, including preoperative data, postoperative surgical results, and audiological performance (aided and unaided pure tone audiometry and aided and unaided speech tests).

Large scale coherent magnetohydrodynamic oscillations in a sunspot.

Although theoretically predicted, the simultaneous excitation of several resonant modes in sunspots has not been observed. Like any harmonic oscillator, a solar magnetic flux tube can support a variety of resonances, which constitute the natural response of the system to external forcing. Apart from a few single low order eigenmodes in small scale magnetic structures, several simultaneous resonant modes were not found in extremely large sunspots.

Clinical profile and management of revision cochlear implant surgeries.

Objectives: To discuss our experience with managing cochlear implant cases that required revision surgery.

Methods: A retrospective case series study including data from 922 cochlear implant patients at an academic tertiary center was evaluated retrospectively. All patients who underwent revision cochlear implant (CI) surgery between January 2011 and July 2017 were included.

Feasibility of Day Surgery for Cochlear Implantation under Conscious Sedation with Same-Day Fitting.

Objectives: To evaluate the feasibility of performing cochlear implantation under conscious sedation (CS) as day surgery with same-day fitting.

Materials And Methods: All patients underwent cochlear implantation under CS between November 2017 and April 2018. The data collected included demographic information, preoperative clinical characteristics, surgical details, postoperative fitting information, and side effects, if any.

A review of the valorization and management of industrial spent catalyst waste in the context of sustainable practice: The case of the State of Kuwait in parallel to European industry.

Industrial solid waste management encompasses a vital part of developed and developing countries strategies alike. It manages waste generated from vital industries and governs the hazardous waste generated as a major component of integrated waste management strategies. This article reviews the practices that govern the management approaches utilized in the developed world for industrial spent catalysts.

Insights into the evaluation of the abiotic and biotic degradation rate of commercial pro-oxidant filled polyethylene (PE) thin films.

In this study, commercial products formulated from polyethylene (PE) with pro-oxidant additives, were subjected to abiotic and biotic environments. The materials were presumed to be oxo-biodegradable plastics with thicknesses varying between 30 and 70 μm, and calcium carbonate (CaCO) filler content reaching up to 11 wt%. Accelerated (aging) weathering tests conducted revealed that UV radiation triggered the biodegradation mechanism.

Complications of post-cochlear implantation in 1027 adults and children.

Background: The number of cochlear implant (CI) recipients is increasing so there needs to be greater awareness of possible CI complications.

Objectives: Describe complications of CI.

Design: Retrospective, descriptional.

A technique to facilitate ceramic veneer cementation.

This report describes a technique to facilitate ceramic veneer cementation. By stabilizing a ceramic veneer in its fully seated position with miniature wooden spring clips before resin polymerization, excess luting resin cement can be removed from ceramic veneer margins without the risk of veneer dislodgement or fracture.

Depression and anxiety among hypertensive and diabetic primary health care patients. Could patients' perception of their diseases control be used as a screening tool?

To measure the frequency and identify risk factors of depression and anxiety among diabetic and hypertensive primary health care (PHC) patients. Also to assess whether patients' perception of their chronic diseases control and sleep disturbance could serve as screening tools for depression and anxiety. Methods: This cross-sectional study of 368 PHC patients was conducted in AlKhobar city, Kingdom of Saudi Arabia between April and May 2015.

Metabolic Syndrome Presenting as Abdominal Pain.

Metabolic syndrome represents a sum of risk factors that lead to the occurrence of cardiovascular and cerebrovascular events. The early detection of metabolic syndrome is extremely important in adults who are at risk. Although the physiopathological mechanisms of the metabolic syndrome are not yet clear, insulin resistance plays a key role that could explain the development of type 2 diabetes mellitus in untreated metabolic syndrome patients.

Management of surgical difficulties during cochlear implant with inner ear anomalies.

Objective: To review the difficulties that can occur during cochlear implant surgery in patients with inner ear abnormalities and the management thereof.

Methods: A retrospective chart review of 316 patients who received cochlear implants was conducted. The data collected included the types of inner ear anomalies, intraoperative findings, and the clinical management strategies.

Prevalence of inner ear anomalies among cochlear implant candidates.

Objectives: To determine the prevalence of inner ear anomalies and the frequency of different anomaly types among cochlear implant recipients.

Methods: This study included a retrospective chart review of all patients who received cochlear implants between January 2009 and January 2013 in King Abdulaziz University Hospital cochlear implant program in Riyadh, Saudi Arabia. All subjects underwent thin-cut CT of the temporal bone and MRI.