Synopsis of recent research by authors named "Alden Dewey"
- Alden Dewey's recent research encompasses both pediatric oncology, as seen in his case report on pediatric parathyroid carcinoma, and acute myeloid leukemia (AML), highlighting a focus on innovative therapeutic targets for challenging malignancies.
- His work on acid ceramidase reveals its upregulation in AML, suggesting it as a potential novel therapeutic target due to its role in sphingolipid dysregulation, which contributes to cancer cell survival and proliferation.
- Dewey has also contributed to the understanding of Bcl-2 family proteins, particularly through the discovery of marinopyrrole A as a selective Mcl-1 antagonist, addressing the challenge of resistance in cancer treatments that target pro-survival proteins.
