Publications by authors named "Aldara Molina"
Article Synopsis
- PRC2, particularly its subunit EZH2, is found to regulate how carcinoma cells change their characteristics by influencing their states between epithelial and mesenchymal forms.
- EZH2 plays a crucial role during the epithelial-mesenchymal transition (EMT) by repressing mesenchymal genes in lung cancer and plays a similar role in breast cancer.
- This research suggests that the PRC2 mechanism for controlling genes related to cell movement and transition is conserved across different types of carcinomas, highlighting its importance in cancer progression.
Article Synopsis
- The text discusses the significance of the epithelial to mesenchymal transition (EMT) in cancer spread, highlighting the need to understand its molecular basis for developing better treatments.
- It emphasizes the role of epigenetic regulators, specifically the Polycomb Repressive Complex 2 (PRC2) protein EZH2, in maintaining the epithelial state of lung carcinoma cells and its relationship with mesenchymal gene transcription.
- The study reveals that inhibiting or removing EZH2 allows cancer cells to stay in a mesenchymal state, which may impact tumor progression, suggesting that EZH2 inhibitors could be potential therapeutic targets for cancer treatment.
Mammals optimize their physiology to the light-dark cycle by synchronization of the master circadian clock in the brain with peripheral clocks in the rest of the tissues of the body. Circadian oscillations rely on a negative feedback loop exerted by the molecular clock that is composed by transcriptional activators Bmal1 and Clock, and their negative regulators Period and Cryptochrome. Components of the molecular clock are expressed during early development, but onset of robust circadian oscillations is only detected later during embryogenesis.
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