Publications by authors named "Alcides Munguambe"
Background: Meningitis remains an important cause of morbi-mortality in adults in sub-Saharan Africa. Data on the etiological investigation of meningitis in adults in Mozambique is limited and most studies were conducted in southern Mozambique. Identification of the etiology of meningitis in adults are crucial to guide prevention and treatments strategies.
View Article and Find Full Text PDFCharacterization of strains of Neisseria meningitidis causing meningococcal meningitis in Mozambique, 2014: Implications for vaccination against meningococcal meningitis.
PLoS One
February 2019
Introduction: In sub Saharan Africa, the epidemiology, including the distribution of serogroups of strains of N. meningitidis is poorly investigated in countries outside "the meningitis belt". This study was conducted with the aim to determine the distribution of serogroups of strains of N.
View Article and Find Full Text PDFSerotype distribution and antimicrobial resistance of Streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategy.
BMC Microbiol
June 2016
Article Synopsis
- S. pneumoniae is a primary cause of acute bacterial meningitis in children, prompting a study on the effectiveness of the newly introduced PCV-10 vaccine in Mozambique.
- Out of 352 cerebrospinal fluid samples collected, 119 tested positive for S. pneumoniae and were serotyped, revealing prevalent serotypes and identifying regional differences in serotype distribution across Northern and Southern Mozambique.
- The study suggests that switching from the PCV-10 vaccine to the PCV-13 formulation could significantly enhance protection against the invasive strains of S. pneumoniae, especially since PCV-10 doesn't cover certain prevalent serotypes.
Frequency of Pathogenic Paediatric Bacterial Meningitis in Mozambique: The Critical Role of Multiplex Real-Time Polymerase Chain Reaction to Estimate the Burden of Disease.
PLoS One
May 2016
Background: In Sub-Saharan Africa, including Mozambique, acute bacterial meningitis (ABM) represents a main cause of childhood mortality. The burden of ABM is seriously underestimated because of the poor performance of culture sampling, the primary method of ABM surveillance in the region. Low quality cerebrospinal fluid (CSF) samples and frequent consumption of antibiotics prior to sample collection lead to a high rate of false-negative results.
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