Publications by authors named "Alchiede Simonato"
Article Synopsis
- The study aimed to develop a machine-learning model to predict the risk of sepsis following retrograde intrarenal surgery (RIRS) for kidney stones, including data from 1,552 patients across 16 centers.* -
- Inclusion criteria for patients were specified, and certain conditions like concomitant ureteral stones were excluded, with antibiotic treatments used where applicable.* -
- The Random Forest algorithm outperformed other machine-learning models, achieving high precision, recall, and accuracy, and a web-based version of the predictive tool is available for use in clinical settings.*
Background And Objectives: We aimed at evaluating the impact of Controlling Nutritional Status (CONUT) score on clinically significant decline in estimated glomerular filtration rate (eGFR) in patients with non-metastatic Clear Cell Renal Cell Carcinoma (ccRCC) undergoing radical nephrectomy (RN).
Materials And Methods: We retrospectively analyzed a multi-institutional cohort of 140 patients with ccRCC who underwent RN between 2016 and 2018 at three Urological Centers. The CONUT score was calculated with an algorithm including serum albumin, total lymphocyte count, and cholesterol.
: To assess the effectiveness of Platelet Concentrates (PCs) in the contest of Hemorrhagic, Actinic, and Radiation Cystitis, plus Urethral Obstruction or Stenosis. : Open article in English or Italian regarding in situ applications of PCs for the selected pathologies. : MEDLINE, Cochrane Library, and ELSEVIER.
View Article and Find Full Text PDFObjective: Prostate cancer, the second most diagnosed cancer among men, requires precise diagnostic techniques to ensure effective treatment. This review explores the technological advancements, optimal application conditions, and benefits of targeted prostate biopsies facilitated by multiparametric magnetic resonance imaging (mpMRI).
Methods: A systematic literature review was conducted to compare traditional 12-core systematic biopsies guided by transrectal ultrasound with targeted biopsy techniques using mpMRI.
Bladder cancer (BC) is the tenth most commonly diagnosed malignancy worldwide. In approximately 25% of cases, it presents as a muscle-invasive disease, requiring a radical treatment. Traditionally, the mainstay of treatment has been radical cystectomy (RC), but in the last decade, bladder-sparing treatments have been gaining growing interest.
View Article and Find Full Text PDFArticle Synopsis
- The systematic review evaluated the status of new robotic systems approved for urological surgery, focusing on their evolution based on the IDEAL framework.
- It found 74 studies, with 90.5% being noncomparative, while only one randomized trial compared the KangDuo system with the da Vinci system.
- Results showed that the new robotic platforms had similar outcomes to the da Vinci system, but the review highlighted limitations like small sample sizes and the lack of robust comparative studies.
Sepsis is the most serious complication of flexible ureteroscopy (F-URS) and laser lithotripsy. We assessed the influence of positive stone culture (SC) on major infectious complications (sepsis, septic shock). This prospective study enrolled adult patients deemed suitable for F-URS and laser lithotripsy from nine centers (January 2022-August 2023).
View Article and Find Full Text PDFBackground: Radical cystectomy (RC) shows an important impact on quality of life (QoL), for various clinical aspects. The aim of our study was to evaluate the short-term bowel function in patients that underwent RC.
Methods: Two hundred and six patients with MIBC underwent RC with ONB or IC urinary diversion.
Background: Stone nomogram by Micali et al., able topredict treatment failure of shock-wave lithotripsy (SWL), retrograde intrarenal surgery (RIRS) and percutaneous nephrolithotomy (PNL) in the management of single 1-2 cm renal stones, was developed on 2605 patients and showed a high predictive accuracy, with an area under ROC curve of 0.793 at internal validation.
View Article and Find Full Text PDFFluorescence confocal microscopy (FCM) represents a novel diagnostic technique able to provide real-time histological images from non-fixed specimens. As a consequence of its recent developments, FCM is gaining growing popularity in urological practice. Nevertheless, evidence is still sparse, and, at the moment, its applications are heterogeneous.
View Article and Find Full Text PDFIn this study, we explored the incidence of double J (JJ) contamination of patients who underwent an endourological procedure for urinary stones and ureteral stenosis. We developed a prospective study between January 2019 and December 2021. Ninety-seven patients, 54 male and 43 female, were enrolled.
View Article and Find Full Text PDFObjectives: The aim of this study is to assess the aetiology, perioperative outcomes and treatment failure of contemporary patients undergoing open or robot-assisted ureteral reconstruction for iatrogenic injuries.
Patients And Methods: We retrospectively analysed consecutive patients who underwent ureteral reconstruction for iatrogenic injuries at two academic centres 07/2013 and 06/2022. A variety of open or robot-assisted procedures were performed, including uretero-cystoneostomy, Boari bladder flap, uretero-ureterostomy, ileal replacement and pyelo-ureteroplasty.
Introduction: Intestinal anastomosis can be performed by hand suturing (single layer or double layer) or by a mechanical suturing machine. The aim of the study was to compare complications, operative time, and costs of the intestinal anastomosis techniques.
Methods: A retrospective comparative study was conducted including patients who underwent radical cystectomy and uretero-ileo-cutaneostomy or vescica ileale Padovana orthotopic neobladder.
Urothelial carcinoma (UC), the sixth most common cancer in Western countries, includes upper tract urothelial carcinoma (UTUC) and bladder carcinoma (BC) as the most common cancers among UCs (90-95%). BC is the most common cancer and can be a highly heterogeneous disease, including both non-muscle-invasive (NMIBC) and muscle-invasive (MIBC) forms with different oncologic outcomes. Approximately 80% of new BC diagnoses are classified as NMIBC after the initial transurethral resection of the bladder tumor (TURBt).
View Article and Find Full Text PDFSentinel node biopsy (SNB) for prostate cancer (PCa) represents an innovative technique aimed at improving nodal staging accuracy. The routinary adoption of this procedure in patients undergoing radical prostatectomy (RP) might be crucial to identify candidates who could effectively benefit from extensive pelvic lymph nodal dissection (ePLND). Despite some promising results, SNB for PCa is still considered experimental due to the lack of solid evidence and procedural standardization.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of various inflammatory serum markers in predicting complications and readmission following radical cystectomy for bladder cancer.
- The research involved analyzing data from 271 patients who underwent the procedure between 2012 and 2022, utilizing logistic regression for statistical analysis.
- Key findings included that factors like current smoking, high plasma fibrinogen levels, and preoperative anemia were linked to major complications, while elevated C-reactive protein and fibrinogen levels were associated with higher likelihoods of unplanned 30-day readmissions.
Introduction: Since COVID-19 pandemic spread, strict preventive measures were adopted to reduce the risk of transmission. Antiseptic dispensers for hand hygiene were diffusely available for patients and hospital staff. To investigate the prophylactic role played by the strict antiseptic rules adopted during pandemic, the rates of nosocomial urinary infections in 2019 and 2020 were compared.
View Article and Find Full Text PDFArticle Synopsis
- Rectal injury (RI) is a serious complication that can occur after radical prostatectomy (RP), leading to both immediate and long-term health issues like bleeding and rectourethral fistulas (RUF).
- A systematic review of literature identified an overall RI incidence of 0.58%, with higher rates found in open and laparoscopic RP compared to other surgical methods, and associated factors include age (≥60 years) and prior radiation therapy.
- The study suggests that RI, although rare, is more likely in certain patient groups and emphasizes the importance of timely detection to reduce the risk of severe complications, urging the development of a management algorithm for better outcomes.
Background: On March 11 2019, European Medicines Agency (EMA) issues a warning after a review of serious, disabling and potentially permanent adverse events (AEs), particularly on musculoskeletal and nervous system, with quinolone (QN) and fluoroquinolone (FQ) antibiotics. Aim of this study was to evaluate the effect of the EMA warning on the rate of AEs after QN and FQ treatments, reported in the EudraVigilance (EV) database.
Methods: EV database is the system for managing and analyzing information on suspected AEs to medicines which have been authorized or being studied in clinical trials in the European Economic Area (EEA).
Introduction: Eosinophilic cystitis is a rare condition which causes common symptoms and may mimic other conditions. Eosinophilic cystitis has several causes such as hypereosinophilic syndrome, inflammatory diseases, neoplasia, parasites or fungal infection, IgE-related diseases, Drug Reaction and Eosinophilia and Systemic Symptoms (DRESS) syndrome, or Churg-Strauss syndrome. Therefore, differential diagnosis is difficult.
View Article and Find Full Text PDFCorrelation Between Long-Term Acetylsalicylic Acid Use and Prostate Cancer Screening with PSA. Should We Reduce the PSA Cut-off for Patients in Chronic Therapy? A Multicenter Study.
Res Rep Urol
October 2022
Purpose: To evaluate the prostate cancer (PCa) detection rate in men with chronic use of Aspirin and to compare it with the detection rate of non-users.
Patients And Methods: Prospectively maintained database regarding patients undergoing prostate biopsy over the last 10 years in five institutions. Patients were divided into two groups according to their exposure to Aspirin.
Background: Stent encrustation is an uncommon event (13%) with a significant impact in patients' management. Aim of our study was to evaluate the available grading systems for encrusted stents.
Methods: A retrospective analysis of encrusted stents was performed in four Italian centers between 2006 and 2020.
Article Synopsis
- The study looked into how ureteral stenting affects people with a condition called idiopathic retroperitoneal fibrosis (IRF) over a long time.
- Researchers found that there are different treatments available, like medical therapy and stenting, but it's not clear when to take out the stent.
- They think using a special type of surgery might be the best way to help these patients, but more studies are needed to understand the best timing for surgery.