Identification and Characterization of a Novel Gene Rearrangement in an Advanced Colorectal Cancer Patient: A Case Report.

Despite the existence of effective therapy options for patients with localized colorectal cancer, advanced-stage patients have limited therapies. Genomic profiling is a promising tool for guiding treatment selection as well as patient monitoring. Here, we describe a novel gene rearrangement () detected in a patient with advanced colorectal cancer that could be a therapeutic target.

Refrigerated amniotic membrane maintains its therapeutic qualities for 48 hours.

During wound healing, the migration of keratinocytes is critical for wound closure. The application of amniotic membrane (AM) on wounds with challenging contexts (e.g.

Psychological and social factors associated with mental health of European dual career athletes: A systematic review.

Dual careers (DCs) are challenging trajectories followed by athletes willing to develop their academic/professional career with their athletic careers. These trajectories usually entail additional stressors, which can decrease athletes' mental health or even increase their risk of mental ill-health. While existing research has recognized the importance of psychological and social factors in both of these areas separately, we lack systematic knowledge on which factors are associated with European DC athlete mental health outcomes, making evidence-based practice more challenging.

Assessing predictors of adequate individual buprenorphine maintenance dosage for the treatment of opioid use disorder: Listening to the patient.

Objective: Dose optimization plays a key role in determining clinical outcomes in patients on opioid agonist treatment (OAT). The objective of this study was to identify the variables independently associated with buprenorphine/naloxone (B/N) dose adequacy in patients with opiate use disorder (OUD).

Method: Cross-sectional study of a convenience sample of patients with OUD treated with B/N (n = 315) in four regions in Spain.

Multimerization of HIF enhances transcription of target genes containing the hypoxia ancillary sequence.

Transcriptional activity of the hypoxia inducible factor (HIF) relies on the formation of a heterodimer composed of an oxygen-regulated α-subunit and a stably expressed β-subunit. Heterodimeric HIF activates expression by binding to RCGTG motifs within promoters of hypoxia-activated genes. Some hypoxia targets also possess an adjacent HIF ancillary sequence (HAS) reported to increase transcription but whose function remains obscure.

Perfectionistic Environments and Irrational Beliefs on the Transition to Elite Athletic Performance: A Longitudinal Study.

This study aimed to longitudinally evaluate talented athletes' levels of perfectionism, irrational beliefs, and motivations with regard to their athletic careers. A total of 390 athletes from U14, U16, and junior categories ( = 15.42) answered shortened versions of the Sport-MPS2, iPBI, and BRSQ during two consecutive seasons, along with questions referring to their current and predicted prioritization of sports and education.

Measuring optimal psychological states: Proposal of two brief versions to measure flow and clutch in athletes.

Background: The study of sports experiences with high levels of performance has led to the observation of two psychological states categorized as optimal, denominated flow and clutch. The objective of this study is to design and validate two brief scales version to measure flow and clutch.

Methods: Following the MIMO (Maximum Information, Minimum Discomfort) protocol, three studies are carried out: In Study 1, we developed the short versions of the questionnaires based on theory-driven and data-driven criteria; in Study 2, we used quantitative criteria to validate the short versions; and in Study 3, we checked the final version of each scale to observe their statistical validity and their relation to other variables.

A case of inter-assay HbA1c discrepancy due to Hemoglobin G-Copenhagen.

Background And Objective: A clinician was intrigued about HbA1c upper 9% (75 mmol/mol) in a 76 year-old women with normal glycemia. Further explorations were performed in order to understand this discordance.

Methods: First HbA1c test was performed on a HLC -723 G11 apparatus (Tosoh Bioscience) and thereafter compared to the HLC-723-G8 (Tosoh Bioscience), the Capillaris 3 Tera (Sebia) and the DCA Vantage point of care testing (POCT) (Siemens) apparatus.

Perceptions of the Educational Community on the Inclusion and Presence of Students with SEN in Mainstream Schools: A Mixed Study.

Achieving inclusive education is a primary challenge for the educational community. Inclusion refers to equal access to education-to the presence, participation and learning of all students. Offering an inclusive education requires all students to share time and space together in the mainstream classroom, that the educational community manifests a positive attitude towards diversity, and that educational centers plan to welcome diversity in their classrooms.

Modeling an Edge Computing Arithmetic Framework for IoT Environments.

IoT environments are forecasted to grow exponentially in the coming years thanks to the recent advances in both edge computing and artificial intelligence. In this paper, a model of remote computing scheme is presented, where three layers of computing nodes are put in place in order to optimize the computing and forwarding tasks. In this sense, a generic layout has been designed so as to easily achieve communications among the diverse layers by means of simple arithmetic operations, which may result in saving resources in all nodes involved.

Arithmetic Framework to Optimize Packet Forwarding among End Devices in Generic Edge Computing Environments.

Multi-access edge computing implementations are ever increasing in both the number of deployments and the areas of application. In this context, the easiness in the operations of packet forwarding between two end devices being part of a particular edge computing infrastructure may allow for a more efficient performance. In this paper, an arithmetic framework based in a layered approach has been proposed in order to optimize the packet forwarding actions, such as routing and switching, in generic edge computing environments by taking advantage of the properties of integer division and modular arithmetic, thus simplifying the search of the proper next hop to reach the desired destination into simple arithmetic operations, as opposed to having to look into the routing or switching tables.

Modeling of a Generic Edge Computing Application Design.

Edge computing applications leverage advances in edge computing along with the latest trends of convolutional neural networks in order to achieve ultra-low latency, high-speed processing, low-power consumptions scenarios, which are necessary for deploying real-time Internet of Things deployments efficiently. As the importance of such scenarios is growing by the day, we propose to undertake two different kind of models, such as an algebraic models, with a process algebra called ACP and a coding model with a modeling language called Promela. Both approaches have been used to build models considering an edge infrastructure with a cloud backup, which has been further extended with the addition of extra fog nodes, and after having applied the proper verification techniques, they have all been duly verified.

Where Did All the Sport Go? Negative Impact of COVID-19 Lockdown on Life-Spheres and Mental Health of Spanish Young Athletes.

During the 2020, the pandemic caused by the massive spread of the SARS-CoV-2 coronavirus (COVID-19) resulted in a global crisis. In Spain, the COVID-19 pandemic caused a lockdown for almost 100 days and forced the sudden stop of sport practices and competitions. This interruption had a negative impact on high-level athletes' mental health.

Factors associated with the absence of cocaine craving in treatment-seeking individuals during inpatient cocaine detoxification.

Background: Anecdotal evidence suggests a substantial proportion of individuals with cocaine use disorder do not report craving during inpatient detoxification.

Objective: To examine prevalence and clinical correlates of consistent absence of cocaine craving among inpatients during detoxification. We hypothesized that craving absence would be associated with less severity of cocaine use, depression, and anxiety.

Fuelling the passion: Psychological needs and behavioural regulations as antecedents of passion for football.

The purpose of the present study was to examine the motivational antecedents of passion for sport by testing a model where players' satisfaction of the three basic psychological needs was expected to predict their harmonious and obsessive passions through the mediation of autonomous and controlled motivations. Four-hundred eighty-seven elite U18 male football players ( = 17.43,  = 0.

Towards a common metric for assessing heroin-dependent patient satisfaction with medications: Testing methadone and buprenorphine-naloxone.

Background: Patient satisfaction with methadone or buprenorphine-naloxone can be multidimensionally and specifically assessed by using, respectively, the Scale to Assess Satisfaction with Medications for Addiction Treatment-Methadone for Heroin addiction (SASMAT-METHER) or the SASMAT-Buprenorphine-Naloxone for Heroin addiction (SASMAT-BUNHER). The factor structures of the SASMAT-METHER and SASMAT-BUNHER show substantial commonalities. The objective of the present study is to evaluate the replicability of the SASMAT-METHER factor structure using data from the SASMAT-BUNHER development study in order to obtain an instrument that can be used to compare patient satisfaction with methadone vs.

Ethanolamine Oleate for Bronchopleural Fistula: Case Series.

Background: Bronchopleural fistula (BPF) is a severe complication of pulmonary resection associated with high morbidity and mortality. Treatment options include both surgical and endoscopic procedures. The size of the fistula and the functional status of the patient are decisive factors in the choice of treatment.

Schools That Promote the Improvement of Academic Performance and the Success of All Students.

The movement for effective schools and school improvement has enjoyed a long history, at both the theoretical and practical level. The contextual variables focused on the educational process of the classrooms have been identified in numerous investigations, concluding that the improvement of academic performance is a key element of the movement. The main objective of this research is focused on verifying the effectiveness of the treatment based on collaborative/cooperative learning methodologies and projects to improve the linguistic and mathematical competence as an enhancing element of academic performance.

Quality of life and well-being from the perspective of patients on opioid agonist maintenance treatment: study protocol for a systematic review of qualitative research and a scoping review of measures.

Background: Opioid agonist maintenance treatment (OAMT) is a first-line treatment for heroin dependence, but its effectiveness has been assessed primarily through clinical outcomes with a limited attention to patient perspectives. Despite the increased use of patient reported outcome measures their patient-centeredness is highly questionable. This is the protocol of a systematic review of qualitative research on how OAMT users construct the meaning of their quality of life and well-being and a scoping review of instruments that measure these domains.

Heroin-dependent patient satisfaction with methadone as a medication influences satisfaction with basic interventions delivered by staff to implement methadone maintenance treatment.

Purpose: The aim of the present study was to test a structural equation model of patient satisfaction with different key facets of methadone maintenance treatment (MMT). In this model, the three dimensions of patient satisfaction with methadone as a medication (ie, personal functioning and well-being, anti-addictive effect on heroin, and anti-addictive effect on non-opioid substances) were expected to predict satisfaction with the basic interventions delivered by the staff of treatment centers to implement MMT.

Patients And Methods: A sample of 210 heroin-dependent patients, resistant to MMT treatment (mean age =41.

Development and validation of the scale to assess satisfaction with medications for addiction treatment - Buprenorphine-naloxone for heroin addiction (SASMAT-BUNHER).

Background: Until now, no specific tool has been available to measure heroin-dependent patient satisfaction with buprenorphine-naloxone as a medication. The purpose of the present study was to develop the Scale to Assess Satisfaction with Medications for Addiction Treatment-Buprenorphine-Naloxone for Heroin addiction (SASMAT-BUNHER) and to examine its validity and reliability.

Methods: The SASMAT-BUNHER was developed from a pool of 44 self-administered items grouped into nine theoretical domains, as follows: Overall Satisfaction, Pharmacotherapy, Initiation, Anti-Addictive Effect on Heroin, Mental State, Physical State, Personal Functioning, Acceptability, and Anti-Addictive Effect on Secondary Substances.

Evidence of validity and reliability of the Opiate Dosage Adequacy Scale (ODAS) in a sample of heroin addicted patients in buprenorphine/naloxone maintenance treatment.

Objective: The Opiate Dosage Adequacy Scale (ODAS) is a clinical tool to individually measure the "adequacy" of opioid doses in patients on maintenance treatment. The aim of this paper is to provide evidence for the validity and reliability of the ODAS in a sample of patients in buprenorphine/naloxone (B/N) maintenance treatment.

Method: Cross-sectional study of a convenience sample of B/N-treated patients (n = 316) from four Autonomous Communities in Spain.

Patient perception of methadone dose adequacy in methadone maintenance treatment: The role of perceived participation in dosage decisions.

Objective: In clinical practice, methadone maintenance treatment (MMT) entails tailoring the methadone dose to the patient's specific needs, thereby individualizing treatment. The aim of this study was to identify the independent factors that may significantly explain methadone dose adequacy from the patient's perspective.

Method: Secondary analysis of data collected in a treatment satisfaction survey carried out among a representative sample of MMT patients (n=122) from the region of La Rioja (Spain).