Publications by authors named "Albon Wu"

Article Synopsis
  • Alternative splicing is a cellular process in eukaryotes that produces multiple protein isoforms from a single gene, influencing protein functions and interactions.
  • The ASpdb database was developed to enhance understanding of alternative splicing by providing structures and models for over 10,000 human protein isoforms, including both canonical and alternative forms.
  • ASpdb offers detailed information on splicing events, 3D structures, sequence variations, and comparative analysis tools, making it a key resource for research in structural biology and disease mechanisms.
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Article Synopsis
  • Alternative splicing in eukaryotes modifies pre-mRNA to produce different protein isoforms from a single gene, but there's limited data on how this affects protein structures.
  • Using AlphaFold 2, researchers analyzed the structural impacts of alternative splicing on about 3,000 human genes, discovering significant changes in protein structures, particularly in coils and beta-sheets.
  • The study highlighted important findings, including connections between alternative splicing and protein features in Septin-9, as well as potential missense mutations in Tau that may relate to Alzheimer's disease.
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Hand gesture recognition using high-density surface electromyography (HD-sEMG) has gained increasing attention recently due its advantages of high spatio-temporal resolution. Convolutional neural networks (CNN) have also recently been implemented to learn the spatio-temporal features from the instantaneous samples of HD-sEMG signals. While the CNN itself learns the features from the input signal it has not been considered whether certain pre-processing techniques can further improve the classification accuracies established by previous studies.

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Three-dimensional (3D) cell culture based on polymer scaffold provides a promising tool to mimic a physiological microenvironment for drug testing; however, the next-generation cell activity monitoring technology for 3D cell culture is still challenging. Conventionally, drug efficacy evaluation and cell growth heavily rely on cell staining assays, using optical devices or flow cytometry. Here, we report a dual-function polymer scaffold (DFPS) composed of thermosensitive, silver flake- and gold nanoparticle-decorated polymers, enabling conductance change upon cell proliferation or death for cell activity monitoring and drug screening.

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