Publications by authors named "Albina V Madzhuga"
Article Synopsis
- Three different types of fucoidans from brown seaweed were analyzed for their ability to prevent blood clotting and reduce thrombus formation using various lab tests.
- The structural features influenced their effectiveness, with fucoidan from Saccharina latissima (SL) being the most effective, while the one from Cladosiphon okamuranus (CO) showed no activity at all, even in high amounts.
- Adding sulfate groups improved activity in some cases but decreased it in others, and the most effective compounds worked by forming complexes with certain proteins involved in blood clotting.
Background: In experimental systems, interference with coagulation can affect tumor biology. We suggested that abnormal coagulation could be a negative predictor for response to immunotherapy and survival among patients with metastatic renal cell carcinoma (MRCC).
Methods: To address this issue, retrospective analysis of 289 previously untreated MRCC patients entering on institutional review board-approved clinical trials was conducted between 2003 and 2006.