Publications by authors named "Albin Kjellbom"
Context: Mild autonomous cortisol secretion (MACS) is associated with increased mortality in patients with adrenal incidentalomas, but little is known regarding the potential risk associated with nonfunctional adrenal adenomas (NFAA), which constitute the majority of adrenal incidentalomas.
Objective: Compare mortality risk in patients with NFAA, and different levels of MACS, to matched controls.
Method: This was a retrospective matched cohort study.
Background: Autonomous cortisol secretion in patients with adrenal incidentalomas is associated with increased mortality, but detailed information about the risk associated with specific levels of autonomous cortisol secretion is not available.
Objective: To measure the association between mortality and levels of autonomous cortisol secretion in patients with adrenal incidentalomas.
Design: Retrospective cohort study.
Objective: During the investigation of adrenal incidentalomas, it is important to accurately diagnose autonomous cortisol secretion (ACS) but the specificity of cortisol ≥50 nmol/L after overnight dexamethasone suppression (cortisol ) is low. Therefore, ACTH following overnight dexamethasone suppression (ACTH ) and cortisol following a 2-day dexamethasone suppression test (cortisol ) were examined as markers of HPA axis suppression during ONDST.
Design: This cross-sectional study examined patients with adrenal incidentalomas and basal ACTH ≥ 2.
Objective: Autonomous cortisol secretion and possible autonomous cortisol secretion (ACS/pACS) are associated to an increase of cardiovascular risk factors such as hypertension, diabetes mellitus and dyslipidaemia. To our knowledge, the prevalence of smoking, another well-established risk factor for cardiovascular disease, has not been studied in detail in people with ACS/pACS or adrenal incidentalomas.
Methods: Patients with adrenal incidentalomas were examined with the 1-mg overnight dexamethasone suppression test (cortisolONDST).
Objective: ACTH is considered a weak marker for autonomous cortisol secretion (ACS) in patients with adrenal incidentalomas (AIs). Our aim was to investigate suppressed basal ACTH as a marker of ACS and to elucidate why this criterion is of limited value.
Methods: Basal ACTH and cortisol after overnight dexamethasone suppression test (cortisolONDST) were measured in 198 patients with unilateral AI and at 2-year follow-up.