Publications by authors named "Albertus D M E Osterhaus"
Article Synopsis
- Dogs have an exceptional sense of smell and can be trained to detect diseases, showing promise in medical detection applications.
- While medical detection dogs have potential, their use is still developing compared to the established roles of dogs in law enforcement and customs.
- Factors such as odors from diseases, genetics, and environment influence a dog's ability to detect scents, highlighting the need for standardization before their widespread use in medical settings.
Background: The main strategy to contain the current SARS-CoV-2 pandemic remains to implement a comprehensive testing, tracing and quarantining strategy until vaccination of the population is adequate. Scent dogs could support current testing strategies.
Methods: Ten dogs were trained for 8 days to detect SARS-CoV-2 infections in beta-propiolactone inactivated saliva samples.
Background: As the COVID-19 pandemic continues to spread, early, ideally real-time, identification of SARS-CoV-2 infected individuals is pivotal in interrupting infection chains. Volatile organic compounds produced during respiratory infections can cause specific scent imprints, which can be detected by trained dogs with a high rate of precision.
Methods: Eight detection dogs were trained for 1 week to detect saliva or tracheobronchial secretions of SARS-CoV-2 infected patients in a randomised, double-blinded and controlled study.
Analysis of Mouse Brain Transcriptome After Experimental Duvenhage Virus Infection Shows Activation of Innate Immune Response and Pyroptotic Cell Death Pathway.
Front Microbiol
March 2018
Article Synopsis
- Rabies is a serious neglected disease that leads to fatal brain inflammation (encephalitis), with research mostly focused on the rabies virus (RABV) while less is known about other related viruses like Duvenhage.
- Researchers studied how the immune system responds in mice infected with Duvenhage virus compared to RABV, revealing similar patterns of gene expression that increase immune signaling molecules.
- Notably, they found that neuron cell death happens through a specific inflammatory process (pyroptosis) rather than typical apoptosis, highlighting potential new targets for developing treatments against rabies.
To date, vaccination is the most cost-effective strategy to combat infectious diseases. Recently, a productivity gap affects the pharmaceutical industry. The productivity gap describes the situation whereby the invested resources within an industry do not match the expected product turn-over.
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