Probability of high-risk genetic matching with oocyte and semen donors: complete gene analysis or genotyping test?

Purpose: To estimate the probability of high-risk genetic matching when assisted reproductive techniques (ART) are applied with double gamete donation, following an NGS carrier test based on a complete study of the genes concerned. We then determine the results that would have been obtained if the genotyping tests most widely used in Spanish gamete banks had been applied.

Methods: In this descriptive observational study, 1818 gamete donors were characterised by NGS.