Bisphenol A Modulates Autophagy and Exacerbates Chronic Kidney Damage in Mice.

Background: Bisphenol A (BPA) is a ubiquitous environmental toxin that accumulates in chronic kidney disease (CKD). Our aim was to explore the effect of chronic exposition of BPA in healthy and injured kidney investigating potential mechanisms involved.

Methods: In C57Bl/6 mice, administration of BPA (120 mg/kg/day, i.

Bisphenol S is a haemodialysis-associated xenobiotic that is less toxic than bisphenol A.

Background: Bisphenol S (BPS) is a structural analogue of bisphenol A (BPA) that is found in the environment. BPS may accumulate in anuric patients due to decreased urinary excretion. The toxicity and health effects of BPS are poorly characterized.

Influence of dialysis membrane composition on plasma bisphenol A levels during online hemodiafiltration.

Introduction: Bisphenol A (BPA) is an ubiquitous environmental toxin that is also found in dialyzers. Online hemodiafiltration (OL-HDF) more efficiently clears high molecular weight molecules, and this may improve BPA clearance. However, the BPA contents of dialysis membranes may be a source of BPA loading during OL-HDF.

Bisphenol A is an exogenous toxin that promotes mitochondrial injury and death in tubular cells.

Background: Uremic toxins that accumulate in chronic kidney disease (CKD) contribute to CKD complications, such as CKD progression. Bisphenol A (BPA) is a ubiquitous environmental toxin, structurally related with p-cresol, that accumulates in CKD. Our aim was to characterize the nephrotoxic potential of BPA.