Cellular Diversity and Differential Subcellular Localization of the G-Protein G Subunit in the Mouse Cerebellum.

Heterotrimeric guanine nucleotide-binding proteins (G proteins) transduce signals from G protein-coupled receptors (GPCRs) to effector ion channels and enzymes G, a member of the pertussis toxin-sensitive G family, is widely expressed in the brain, although its role within a neuronal context remains largely unknown. Using immunohistochemical and quantitative immunoelectron microscopy techniques, we have investigated the expression, cellular and subcellular localization of G in the cerebellar cortex. Histoblot revealed that G is expressed in many brain regions, including the cerebellum.