Publications by authors named "Alberto Rapella"
Leuk Lymphoma
December 2024
Article Synopsis
- Richter's transformation (RT) is when chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) changes into a more aggressive form, typically diffuse large B-cell lymphoma, leading to a poor prognosis.
- The presence of clonal relationships in about 80% of RT cases significantly influences the overall prognosis and survival rates.
- While traditional treatments like chemoimmunotherapy have limited effectiveness due to genetic mutations, new therapies involving pathway inhibitors, bispecific antibodies, and CAR T-cell therapy are being researched as promising alternatives.
