Introduction: The Neurofibromatosis type I (NF1) is an autosomal dominant syndrome that affects 1/3000-1/4000 individuals. Patients with this condition are predisposed to different tumors, like neurofibromas, optic nerve gliomas, gastrointestinal stromal tumors (GIST) and breast cancers.
Presentation Of Case: A 78-year-old female patient affected by NF1 in May 2018 during follow-up for a carcinoma of the right breast had persistent anemia requiring regular blood transfusions.