Publications by authors named "Alberto Gutierrez Calvo"
This review focuses on the latest advancements in using biomarkers to diagnose, predict outcomes, and guide the treatment of different types of thyroid cancer, such as anaplastic, papillary, medullary, and follicular thyroid carcinoma. We highlight the key role of both traditional and new biomarkers in improving the treatment of these cancers. For anaplastic thyroid cancer, biomarkers are crucial for detecting distant metastases and making treatment decisions.
View Article and Find Full Text PDFGastric cancer ranks fifth in both world prevalence and lethality, with a 5-year survival of less than 30%. HLA-G, a non-classical class I HLA gene, has emerged as a potential marker for cancer susceptibility and prognosis due to its immunomodulatory properties. Its level of expression is regulated by polymorphisms in the 3' untranslated region (3'UTR) polymorphisms, which form various combined haplotypes (UTR-1 to -9).
View Article and Find Full Text PDFAcute kidney injury (AKI) is a frequent complication in patients undergo-ing cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) due to a combination of several factors: increased intra-abdominal pressure, heat stress and drug tox-icity. Patients admitted to Intensive Care Unit after CRS and HIPEC during 129 months. Data recorded were: demographic characteristics; severity of illness, haematology and basic chemistry panels (renal function and electrolytes), type of cancer and extension, HIPEC drug and temperature, fluid balance, ICU and hospital stay and mortality.
View Article and Find Full Text PDFThe Human Leukocyte Antigen (HLA) system contains a set of genes involved at many levels in the innate and adaptive immune response. Among the non-classical HLA class I genes, HLA-G stands out for the numerous studies about its pivotal role in regulating/modulating immune responses. Also, its involvement in extravillous cytotrophoblast function, viral infections, autoimmunity, and cancer has been extensively documented.
View Article and Find Full Text PDFCalcifying fibrous tumor (CFT) is a rare, benign, mesenchymal tumor. It has a slight female predominance, and it can appear in any range of age. It can be in the extremities, neck, and gastrointestinal tract, but it has also been described in other locations.
View Article and Find Full Text PDFArticle Synopsis
- Colorectal cancer is a major health issue, being the fourth leading cause of cancer deaths, with rectal cancer contributing significantly to these statistics; recent studies show promising advancements in neoadjuvant therapies.
- * A study involving 181 patients with locally advanced rectal cancer examined the effects of neoadjuvant chemoradiotherapy on tumor regression and surgical outcomes, utilizing the Mandard grading system for analysis.
- * The findings indicated that greater tumor regression correlates with improved disease-free survival rates and reduced local recurrence and distant metastasis, highlighting the importance of tumor response to therapy on long-term disease progression.
Pancreatic cancer is a type of gastrointestinal tumor with a growing incidence and mortality worldwide. Pancreatic ductal adenocarcinoma (PDAC) constitutes 90% of cases, and late-stage diagnosis is common, leading to a 5-year survival rate of less than 10% in high-income countries. The use of biomarkers has different proven translational applications, facilitating early diagnosis, accurate prognosis and identification of potential therapeutic targets.
View Article and Find Full Text PDFArticle Synopsis
- Thyroid abscesses are rare but can occur in patients with weakened immune systems or existing thyroid issues; early diagnosis and treatment with antibiotics and abscess drainage is essential.
- A case study highlights a 48-year-old healthy male who developed a thyroid abscess after recent acute prostatitis treatment, presenting with neck pain and swelling that blocked airway movement.
- After confirming the abscess with imaging, the patient underwent an emergency hemithyroidectomy, resulting in a successful recovery without complications like voice changes or recurrence.
Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID).
Surg Oncol
February 2024
Article Synopsis
- The study focuses on the recurrence of isolated pancreatic metastases from Renal Cell Carcinoma (RCC) and evaluates the outcomes of repeat pancreatic resections after initial surgery.
- It involved a retrospective analysis of 131 resections in 116 patients from January 2010 to May 2020, comparing those who had single versus iterative pancreatic surgeries.
- Results indicated that while disease-free survival (DFS) rates were slightly better in the iterative group, overall survival (OS) rates were similar for both groups, suggesting that repeat surgery is a viable option for managing RCC-related pancreatic metastases.
Article Synopsis
- * CRC primarily spreads to lymph nodes, liver, and lungs, while bone metastases are rare and usually appear alongside other metastases, significantly impacting patient quality of life and prognosis.
- * The study details a case of a patient who had successful surgery for stage IV rectal adenocarcinoma but developed a rare costal wall metastasis 79 months later, highlighting the need for personalized patient management.
Peritoneal metastasis (PM) is the primary pattern of metastasis for primary tumours of the appendix, ovary, and peritoneal mesothelioma [...
View Article and Find Full Text PDFArticle Synopsis
- Spontaneous cervical hematoma often arises from bleeding in or around the parathyroid gland, typically linked to conditions like giant adenomas or hyperplasia, and can lead to severe complications if it compresses the airway.
- For stable patients, treatment generally includes monitoring and possible delayed surgery, while those with airway issues require urgent surgical intervention.
- The case study discusses a 78-year-old patient with multiple health issues who experienced neck pain and respiratory problems due to a spontaneous cervical hematoma from a giant parathyroid adenoma, resulting in complicated post-operative recovery.
Article Synopsis
- * A case involving a 77-year-old woman who had surgery for this cancer showed an unusual recurrence in the sigmoid colon nine years after her initial treatment.
- * After performing surgery to remove the affected part of the colon, it was confirmed that the tumor was a metastasis from the original endometrial adenocarcinoma, but the patient responded well and has been disease-free for 18 months post-treatment.
Article Synopsis
- Gallbladder volvulus is a rare cause of acute cholecystitis where the gallbladder twists around its own blood supply, leading to abdominal pain and complications.
- An 87-year-old woman was diagnosed after a CT scan and ultrasound revealed a twisted and distended gallbladder without gallstones, prompting an emergency cholecystectomy.
- Early detection and surgical intervention are critical due to the risk of severe complications like necrosis and perforation, but misdiagnosis is common due to similar symptoms with acute cholecystitis.
Article Synopsis
- * Results show that patients with right-sided (RS) tumors have significantly lower overall survival (OS) and cancer-related survival (CRS) compared to those with left-sided (LS) or rectal tumors, particularly in advanced stages.
- * The research indicates that tumor location is an independent prognostic factor, with RS patients facing greater challenges in survival rates, especially at stage III and IV, highlighting the need for further analysis of these differences.
Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have benefits for survival in some cancers with peritoneal metastasis. Hematologic toxicity described rate is 2 to 38%.
Methods: Patients admitted to an intensive care unit (ICU) after CRS and HIPEC over 78 months.
Treatment of Peritoneal Surface Malignancies by Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Spain: Results of the National Registry of the Spanish Group of Peritoneal Oncologic Surgery (REGECOP).
J Clin Med
May 2023
Introduction: Treatment of Peritoneal Surface Malignancies (PSM) with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has achieved results never seen before in these patients, which classically have a poor prognosis. The possibility of conducting clinical trials in these diseases is complicated, since some of them are rare, so the analysis of large databases provides very valuable scientific information. The aim of this study is to analyze the global results of the National Registry of the Spanish Group of Peritoneal Oncologic Surgery (REGECOP), whose objective is to register all patients scheduled for HIPEC nationwide.
View Article and Find Full Text PDFArticle Synopsis
- Adipocytic tumors are the most common soft tissue cancers, with liposarcoma being the most prevalent malignant type; however, their evolution and prognosis, especially in retroperitoneal areas, haven't been well studied before.
- A retrospective analysis was conducted on 52 patients diagnosed with liposarcoma from 2000 to 2020, categorizing them based on tumor location (retroperitoneal vs. non-retroperitoneal) and examining factors like recurrence, treatment, and mortality.
- The study found significant differences in survival rates of liposarcoma subtypes based on their location, with better outcomes for certain types in non-retroperitoneal regions; surgical margins were crucial for prognosis,
Importance: Peritoneal metastasis in patients with locally advanced colon cancer (T4 stage) is estimated to recur at a rate of approximately 25% at 3 years from surgical resection and is associated with poor prognosis. There is controversy regarding the clinical benefit of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) in these patients.
Objective: To assess the efficacy and safety of intraoperative HIPEC in patients with locally advanced colon cancer.
Article Synopsis
- Uterine carcinosarcoma (UCS) is a rare and aggressive form of endometrial cancer consisting of both carcinomatous and sarcomatous elements, primarily affecting older women.
- A clinical case presented involves a 72-year-old woman experiencing severe abdominal pain, fever, and a large uterine tumor, with surgery recommended as the main treatment approach.
- Despite surgery being the preferred treatment, UCS has a generally poor prognosis with low survival rates due to its malignant nature and potential for metastasis.
The presence of cells with regulatory functions in patients with cancer is one of the mechanisms whereby the immune system cannot confront tumor growth. We sought to determine the prevalence of immunoregulatory T-cell subpopulations, expressing the latency TGFβ-associated peptide (LAP), in patients with gastric adenocarcinoma. T cells were enriched from blood or gastric tissue (tumoral, TT or tumor-free, TF) samples from 22 patients, 6 with early (EGC) and 16 with advanced gastric cancer (AGC).
View Article and Find Full Text PDFArticle Synopsis
- HIPEC (Hyperthermic IntraPEritoneal Chemotherapy) is a promising treatment for peritoneal carcinomatosis that shows improved survival rates compared to traditional therapies, following a thorough cytoreductive surgery.
- A study involving 482 patients from 11 Spanish hospitals evaluated the safety and effectiveness of HIPEC using a closed technique with a CO-agitation system called Combat PRS.
- Results indicated that the mortality rate (1.66%) and morbidity rate (9.96% of serious complications) were comparably low and favorable when compared to standard treatment techniques, with overall survival rates of 86% at one year and 54% at three years.
Article Synopsis
- - The study analyzed survival factors in patients with peritoneal metastasis (PM) from colorectal cancer (CRC), focusing on whether PM was detected simultaneously with the primary tumor or developed later.
- - Out of 1882 colorectal cancer patients treated, 240 (12.8%) were included, revealing that certain factors like KRAS mutation and peritoneal carcinomatosis index (PCI) significantly influenced survival rates, with better outcomes for patients with lower PCI scores.
- - The findings emphasized that PCI remains a critical prognostic indicator, with specific survival rates highlighted based on the categorization of patients by PCI scores and other tumor characteristics.
GECOP-MMC: phase IV randomized clinical trial to evaluate the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) with mytomicin-C after complete surgical cytoreduction in patients with colon cancer peritoneal metastases.
BMC Cancer
May 2022
Background: The French PRODIGE 7 trial, published on January 2021, has raised doubts about the specific survival benefit provided by HIPEC with oxaliplatin 460 mg/m (30 minutes) for the treatment of peritoneal metastases from colorectal cancer. However, several methodological flaws have been identified in PRODIGE 7, specially the HIPEC protocol or the choice of overall survival as the main endpoint, so its results have not been assumed as definitive, emphasizing the need for further research on HIPEC. It seems that the HIPEC protocol with high-dose mytomicin-C (35 mg/m) is the preferred regime to evaluate in future clinical studies.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to investigate how KRAS gene mutations affect survival rates in patients with colorectal cancer and peritoneal metastases.
- It included a cohort of 149 patients diagnosed between 2006 and 2019, revealing that those with wild-type KRAS had better survival rates compared to those with KRAS mutations (35% vs. 14% at 36 months).
- The findings suggest that the KRAS mutation serves as an important prognostic factor for survival in these patients, highlighting its significance in treatment planning.