Publications by authors named "Alberto Feliciano"
Three-Component Synthesis of 2-Amino-3-cyano-4-chromenes, In Silico Analysis of Their Pharmacological Profile, and In Vitro Anticancer and Antifungal Testing.
Alberto Feliciano Omar Gómez-García Carlos H Escalante Mario A Rodríguez-Hernández Mariana Vargas-Fuentes
Pharmaceuticals (Basel)
October 2021
Article Synopsis
- Chromenes are compounds explored for their potential to inhibit topoisomerase and cytochrome enzymes, which are important in the growth of cancer and fungal cells, respectively.* -
- The study focused on synthesizing novel chromene derivatives and testing their anticancer activity, finding them to be more effective than established treatments like cisplatin and topotecan in certain cancer cell lines.* -
- Additionally, these compounds showed promising antifungal activity, with inhibitory concentrations comparable to fluconazole, and molecular docking studies indicated they could effectively interact with the target enzymes, suggesting their potential for further research.*
Article Synopsis
- Fischer carbene complexes (FCCs) are electron-deficient and can react with α,β-unsaturated systems to create various compounds, particularly through higher-order cycloadditions, which involve complex pericyclic reactions.
- These higher-order cycloadditions have significant applications in organic synthesis, leading to the generation of highly selective compounds with diverse structures.
- The review focuses on the advancements in higher-order cycloadditions using FCCs over the past two decades, highlighting improvements in selectivity and the influence of substituents on the resulting structural diversity of carbocycles and heterocycles.