Publications by authors named "Alberto Ambesi-Impiobato"
Mol Cancer Ther
July 2012
Article Synopsis
- T-cell acute lymphoblastic leukemias (T-ALL) are aggressive blood cancers linked to NOTCH1 mutations, and researchers are exploring γ-secretase inhibitors (GSI) like PF-03084014 as potential treatments.
- The study found that combining PF-03084014 with glucocorticoids resulted in a strong antileukemic effect in both lab models and patient samples, enhancing the effectiveness of the treatment.
- Additionally, this combination not only reduced tumor size but also mitigated gastrointestinal side effects caused by PF-03084014, highlighting its potential for treating glucocorticoid-resistant T-ALL.
