Special issue: mathematical methods in the biosciences.

The special issue is available from: https://www.aimspress.com/newsinfo/1079.

A fit of CD4 T cell immune response to an infection by lymphocytic choriomeningitis virus.

We fit an immune response model to data reporting the CD4 T cell numbers from the 28 days following the infection of mice with LCMV. We used an ODE model that was previously used to describe qualitatively the behaviour of CD4 T cells, regulatory T cells (Tregs) and interleukine-2 (IL-2) density. The model considered two clonotypes of T cells in order to fit simultaneously the two time series for the gp61 and NP309 epitopes.