Publications by authors named "Albert Shin"
Trigger valves are fundamental features in capillary-driven microfluidic systems that stop fluid at an abrupt geometric expansion and release fluid when there is flow in an orthogonal channel connected to the valve. The concept was originally demonstrated in closed-channel capillary circuits. We show here that trigger valves can be successfully implemented in open channels.
View Article and Find Full Text PDFExtracellular Vesicles (EVs) are membrane-derived vesicles shed by cells into the extracellular space that play key roles in intercellular communication and other biological processes. As membrane-bound cargos of nucleic acids and other proteins that are abundantly found in virtually every biofluid including blood, urine, and saliva, EVs are widely regarded as promising biomarkers for disease detection. While it is an increasingly promising biofluid from which to isolate EVs, saliva poses challenges due its complexity and heterogeneity-cells, debris, and other proteins can inhibit the isolation of EVs by traditional platforms.
View Article and Find Full Text PDFArticle Synopsis
- Trigger valves are essential components in microfluidic systems that control fluid flow by stopping it at expansions and allowing release through connected channels.
- This study successfully implements trigger valves in open channels and demonstrates how multiple valves can create layered capillary flow alongside main channels.
- A model for flow dynamics at these valves was developed and validated, with implications for applications in biosensing, sample preparation, hydrogel patterning, and organ-on-a-chip technologies.
Background: Patients critically ill with COVID-19 develop acute respiratory distress syndrome (ARDS) and may undergo prone positioning.
Objective: To compare the effects of prone positioning on oxygenation, intensive care unit length of stay, and intubation days in patients with COVID-19 ARDS and patients with non-COVID-19 ARDS.
Methods: A convenience sample of intubated patients with COVID-19 and moderate to severe ARDS (per Berlin criteria) was compared with historical data from a retrospective, descriptive medical record review of patients with non-COVID-19 ARDS.