Manganese-Enhanced Magnetic Resonance Imaging and Studies of Rat Behavior: Transient Motor Deficit in Skilled Reaching, Rears, and Activity in Rats After a Single Dose of MnCl.

Manganese-enhanced magnetic resonance imaging (MEMRI) has been suggested to be a useful tool to visualize and map behavior-relevant neural populations at large scale in freely behaving rodents. A primary concern in MEMRI applications is Mn toxicity. Although a few studies have specifically examined toxicity on gross motor behavior, Mn toxicity on skilled motor behavior was not explored.

Altered brain morphology and functional connectivity reflect a vulnerable affective state after cumulative multigenerational stress in rats.

Prenatal stress is a risk factor for abnormal neuroanatomical, cognitive, behavioral and mental health outcomes with potentially transgenerational consequences. Females in general seem more resilient to the effects of prenatal stress than males. Here, we examined if repeated stress across generations may diminish stress resiliency and cumulatively enhance the susceptibility for adverse health outcomes in females.

Both compensation and recovery of skilled reaching following small photothrombotic stroke to motor cortex in the rat.

Large lesions produced by stroke to the forelimb region of motor cortex of the rat feature post-stroke improvement that in the main is due to compensation. The present study describes both recovery and compensation of forelimb use in a reach-to-eat (skilled reaching) task following small photothrombotic stroke. The rats were pretrained before stroke, and then assessed using endpoint measures and biometric movement analysis during rehabilitation in the acute and chronic post-stroke periods.

Observation of satellite signals due to scalar coupling to spin-1/2 isotopes in solid-state nuclear magnetic resonance spectroscopy.

A method is introduced to select the signal from a spin-1/2 nucleus I specifically bound to another spin-1/2 nucleus S for solid-state magic angle spinning nuclear magnetic resonance (NMR) spectroscopy via correlation through the heteronuclear J coupling. This experiment is analogous to the bilinear rotation decoupling (BIRD) sequence in liquid-state NMR spectroscopy which selects for signals from 1H directly bound to 13C. The spin dynamics of this modified BIRD experiment is described using the product-operator formalism, where experimental considerations such as rotor synchronization and the effect of large chemical shielding anisotropies on I and S are discussed.

Two-compartment radial diffusive exchange analysis of the NMR lineshape of (129)Xe dissolved in a perfluorooctyl bromide emulsion.

Hyperpolarized (129)Xe (xenon) gas dissolved in a perfluorooctyl bromide (PFOB) emulsion stabilized with egg yolk phospholipid (EYP) is a possible contrast agent for quantitative blood flow measurements using magnetic resonance imaging. The NMR line shape of xenon dissolved in PFOB emulsion depends strongly on the exchange of spins between PFOB and water. The exchange in this system depends on three factors: the geometrical factors (i.

Passive shimming of the fringe field of a superconducting magnet for ultra-low field hyperpolarized noble gas MRI.

Hyperpolarized noble gases (HNGs) provide exciting possibilities for MR imaging at ultra-low magnetic field strengths (<0.15 T) due to the extremely high polarizations available from optical pumping. The fringe field of many superconductive magnets used in clinical MR imaging can provide a stable magnetic field for this purpose.

Theoretical signal-to-noise ratio and spatial resolution dependence on the magnetic field strength for hyperpolarized noble gas magnetic resonance imaging of human lungs.

In hyperpolarized noble gas (HNG) magnetic resonance (MR) imaging, the available polarization is independent of magnetic field strength and for large radiofrequency (rf) coils, such as those used for chest imaging, the body noise becomes the primary noise source making signal-to-noise ratio (SNR) largely frequency independent at intermediate field strengths (0.1-0.5 T).

Laser-polarized 129Xe NMR at 1.88 T and 8.5 mT: a signal-to-noise ratio comparison.

The signal-to-noise ratio of nuclear magnetic resonance signals from laser-polarized 129Xe gas was investigated at 8.5 mT and compared to that of signals acquired at 1.88 T.