Publications by authors named "Albert Koroma"
Article Synopsis
- Severe angiopathy contributes to complications in diabetes, but understanding the mechanisms for effective therapies is lacking.
- Injecting ABCB5 stromal precursors into diabetic wounds in mice significantly speeds up healing by boosting blood vessel formation through the release of angiogenin.
- Blocking angiogenin in these precursors slows healing, highlighting its crucial role in tissue repair for diabetic conditions, paving the way for better treatments for nonhealing wounds.
Fibroblasts residing in the connective tissues constitute the stem cell niche, particularly in organs such as skin. Although the effect of fibroblasts on stem cell niches and organ aging is an emerging concept, the underlying mechanisms are largely unresolved. We report a mechanism of redox-dependent activation of transcription factor JunB, which, through concomitant upregulation of p16 and repression of insulin growth factor-1 (IGF-1), initiates the installment of fibroblast senescence.
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