Utilizing drug-target-event relationships to unveil safety patterns in pharmacovigilance.

Introduction: Signal detection is the most pivotal activity of signal management to guarantee that drugs maintain a positive risk-benefit ratio during their lifetime on the market. Signal detection is based on the systematic evaluation of available data sources, which have recently been extended in order to improve timely and comprehensive signal detection of drug safety problems.

Areas Covered: In recent years, attempts have been made to incorporate pharmacological data for the prediction of safety signals.