Publications by authors named "Albert Alain Hagege"
Background: Rheumatic heart disease (RHD) remains a major public health problem worldwide. Although early diagnosis by echocardiography may potentially play a key role in developing active surveillance, systematic evaluation of simple approaches in resource poor settings are needed.
Methods And Results: We prospectively compared focused cardiac ultrasound (FCU) to a reference approach for RHD screening in a school children population.
Aims: Although active-controlled trials with renin–angiotensin inhibitors are ethically mandated in heart failure with reduced ejection fraction, clinicians and regulators often want to know how the experimental therapy would perform compared with placebo. The angiotensin receptor-neprilysin inhibitor LCZ696 was compared with enalapril in PARADIGM-HF. We made indirect comparisons of the effects of LCZ696 with putative placebos.
View Article and Find Full Text PDFAims: Few studies have assessed the effects of cell therapy in non-ischaemic cardiomyopathies which, however, contribute to a large number of cardiac failures. Assuming that such conditions are best suited for a global delivery of cells, we assessed the effects of epicardially delivered adipose tissue-derived stroma cell (ADSC) sheets in a mouse model of dilated cardiomyopathy based on cardiac-specific and tamoxifen-inducible invalidation of serum response factor.
Methods And Results: Three weeks after tamoxifen administration, the function of the left ventricle (LV) was assessed by echocardiography.
Background: Routine management of hypertensive adults is based on assessment of risk factors for coronary artery disease; risk factors for heart failure (HF) remain poorly investigated despite the key role of hypertension in HF development.
Aim: To assess the components of HF risk in hypertensive adults in primary care, compare physicians' estimations of HF and global cardiovascular risks with established calculation algorithms, and assess the concordance of these algorithms.
Methods: O-PREDICT was a transverse, observational, multicentre French survey conducted in 2006 among general practitioners who included the first hypertensive, non-HF patient seen in each of three age classes (<60, 60-70, >70 years).
All patients with suspected angina need rapidly further cardiological examinations to check the diagnosis and fix the prognosis (at least clinical and risk factor evaluations and a resting ECG). The initial non-invasive strategy should include an echocardiography and a stress test (exercise ECG, stress echocardiography or perfusion scintigraphy), followed, in the majority of cases, by a coronary angiography. Lifestyle changes are mandatory and are fully part of secondary prevention: cigarette smoking withdrawal, mediterranean diet (fruit, vegetables, fish and poultry), weight loss, moderate alcohol consumption, increased omega-3 fatty acids and regular physical activity.
View Article and Find Full Text PDFBackground: Transplantation (Tx) of skeletal myoblasts (SM) within an infarcted myocardium improves global left ventricular (LV) function, although a direct systolic effect remains controversial.
Methods And Results: Global and regional LV functions were studied in a sheep model (n=16) of infarction before (baseline), and 4 (M4), and 12 (M12) months after in-scar injections of autologous SM or culture medium (CM). LV end-diastolic volume (EDV), ejection fraction (EF), wall motion score (WMS), and systolic myocardial velocity gradient (MVG) across the scar were measured by echocardiography with tissue Doppler imaging.