Publications by authors named "Albeiro Marrugo Padilla"
Toxicokinetic Profiles and Potential Endocrine Disruption Effects at the Reproductive Level Promoted by Siloxanes Used in Consumer Products.
J Appl Toxicol
October 2024
Article Synopsis
- Siloxanes, or silicones, are compounds composed of alternating silicon and oxygen atoms, and include widely used forms like D4 and D5, which are found in personal care products (PCPs) for their effective emollient properties.
- Concerns have arisen about these compounds as persistent organic pollutants that may pose public health risks, especially given their presence in environmental and biological systems, including breast milk and plasma.
- Research indicates that both D4 and D5 can disrupt endocrine functions and reproductive health, with D4 showing estrogenic activity leading to issues like increased uterine weight and potential cancer risks, while D5 affects follicle growth and hormonal balance, contributing to infertility and other reproductive disorders.
Worldwide, chicken meat is widely consumed due to its low cost, high nutritional value and non-interference with religious or cultural beliefs. However, during animal husbandry chickens are exposed to many chemical substances, including tetracyclines and β-lactams, which are used to prevent and cure several infections. Some residues of these compounds may bioaccumulate and be present in chicken meat after slaughtering, promoting oxidative reactions.
View Article and Find Full Text PDFThis work aimed to evaluate the effect of carbonylation induced by tetracyclines, β-lactams, fluoroquinolones, and pyrethroids in caseins of bovine origin on their immunoreactivity and allergenicity. Using a spectrophotometric method, ELISA, dot-blot, and an IgE-mediated milk allergy mouse model, we confirmed that antibiotics and pesticides at their maximum residue limit, promoted the carbonylation of caseins (among 5.0 ± 0.
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