Publications by authors named "Alba de Martino Rodriguez"
Article Synopsis
- The study investigates the genetic factors linked to severe COVID-19, specifically focusing on hospitalized cases in admixed Americans.
- Researchers conducted the largest genome-wide association study (GWAS) for COVID-19 hospitalization in this population, identifying four significant genetic associations, including two novel loci found in Latin Americans.
- The findings highlight the importance of including diverse populations in genomic research, aiming to improve understanding of genetic risks associated with COVID-19 across different ethnic groups.
Article Synopsis
- A genome-wide study involving nearly 12,000 COVID-19 positive cases in Spain identified significant genetic variants linked to hospitalization, with specific loci associated with males (3p21.31, 21q22.11) and females (9q21.32 near TLE1).
- A second phase combined data with an additional cohort, revealing two new risk loci (9p13.3, 19q13.12) related to candidate genes AQP3 and ARHGAP33, and confirmed earlier findings in males for some loci.
- The analysis highlighted genetic differences in COVID-19 severity between sexes and ages, with more pronounced heritability in males, particularly those over
Aims: Although transplantation of skeletal myoblast (SkM) in models of chronic myocardial infarction (MI) induces an improvement in cardiac function, the limited engraftment remains a major limitation. We analyse in a pre-clinical model whether the sequential transplantation of autologous SkM by percutaneous delivery was associated with increased cell engraftment and functional benefit.
Methods And Results: Chronically infarcted Goettingen minipigs (n = 20) were divided in four groups that received either media control or one, two, or three doses of SkM (mean of 329.
HepaSphere is a new spherical embolic material developed in a dry state that absorbs fluids and adapts to the vessel wall, leaving no space between the particle and the arterial wall. The aim of this study was to elucidate the final in vivo size, deformation, final location, and main properties of the particles when reconstituted with two different contrast media (Iodixanol and Ioxaglate) in an animal model. Two sizes of "dry-state" particles (50-100 and 150-200 microm) were reconstituted using both ionic and nonionic contrast media.
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