Publications by authors named "Alba Soledad Aquino-Dominguez"
Platelets play a crucial role in hemostasis and the immune response, mainly by recognizing signals associated with vascular damage. However, it has recently been discovered that the antimicrobial peptide LL-37 activates platelets in functions related to thrombus formation and inflammation. Therefore, this work aims to evaluate the effect of LL-37 on the activation of antimicrobial functions of human platelets.
View Article and Find Full Text PDFPlatelets play a significant role in hemostasis and perform essential immune functions, evidenced by the extensive repertoire of antimicrobial molecules. Currently, there is no clear description of the presence of azurocidin in human platelets. Azurocidin is a 37 kDa cationic protein abundant in neutrophils, with microbicidal, opsonizing, and vascular permeability-inducing activity.
View Article and Find Full Text PDFArticle Synopsis
- Platelets are immune cells that can secrete proteins with antimicrobial properties, including defensin alpha 1 (DEFA1), which hasn't been fully studied until now.
- This study found that DEFA1 mRNA and protein are present in human platelets and megakaryocytes, confirming their capability to produce this antimicrobial substance.
- When activated, platelets release DEFA1, which can attach back to their surface and combat gram-negative bacteria, highlighting their role in the immune defense.