Publications by authors named "Alba Sanchez-Fernandez"
Article Synopsis
- Researchers are exploring how combining radiotherapy with immunotherapy can improve cancer treatment, as some cancers resist immune checkpoint inhibitors.
- Current methods often struggle because irradiating tumor-draining lymph nodes (DLNs) could inhibit anti-tumor immune responses needed for effective treatment.
- The study shows that applying radiation to DLNs after initial treatment (delayed DLN IR) is more beneficial than doing it beforehand (neoadjuvant), as it helps maintain important immune signaling pathways for better radio-immunotherapy outcomes.
Background: Cancer cell survival under stress conditions is a prerequisite for the development of treatment resistance. The survival kinase DYRK1B is a key regulator of stress survival pathways and might thereby also contribute to radiation resistance. Here we investigate the strategy of targeting DYRK1B in combination with ionizing radiation (IR) to enhance tumor cell killing under stress conditions.
View Article and Find Full Text PDFBackground: Resolution of inflammation is an active and regulated process that leads to the clearance of cell debris and immune cells from the challenged tissue, facilitating the recovery of homeostasis. This physiological response is coordinated by endogenous bioactive lipids known as specialized pro-resolving mediators (SPMs). When resolution fails, inflammation becomes uncontrolled leading chronic inflammation and tissue damage, as occurs in multiple sclerosis (MS).
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- Interleukin 37 (IL-37) is a cytokine that helps suppress inflammation and has potential therapeutic effects in neuroinflammatory diseases like multiple sclerosis (MS).
- The study used a mouse model of MS called experimental autoimmune encephalomyelitis (EAE) to investigate how IL-37 affects inflammation and neurological functions.
- Results showed that IL-37 reduced inflammation and myelin loss in EAE mice through its receptor complex IL1-R5/IL-1R8, but its expression was not upregulated in blood and brain samples from MS patients despite receptor presence.
Interleukin 37 (IL-37) is an anti-inflammatory cytokine of the interleukin 1 family. Transgenic mice expressing the human form of the IL37 gene (hIL-37Tg) display protective effects in several animal models of disease. Previous data from our group revealed that IL-37 limits inflammation after spinal cord injury (SCI) and ameliorates tissue damage and functional deficits.
View Article and Find Full Text PDFIL-1β and IL-18 are pro-inflammatory cytokines that are linked to inflammation. Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome is involved in the maturation and secretion of IL-1β and IL-18 and, thus, plays a key role in the pathogenesis of many inflammatory conditions, including multiple sclerosis (MS). OLT1177™ (Dapansutrile) is a newly developed drug that is safe in humans and inhibits specifically the NLRP3 inflammasome.
View Article and Find Full Text PDFSpinal cord injury (SCI) leads to irreversible devastating neurological disabilities. Accumulated evidence in the literature indicates that the inflammatory response that occurs in the spinal cord following injury contributes importantly to spread tissue damage to healthy regions adjacent to the lesion site, and consequently, to increase neurological deficits. Therefore, targeting inflammation could lead to the development of new therapies to prevent tissue damage and neurological impairments after SCI.
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