Publications by authors named "Alba Hermoso-Lopez"
Growth-associated protein of 43 kDa (GAP43) is a key cytoskeleton-associated component of the presynaptic terminal that facilitates neuroplasticity. Downregulation of GAP43 expression has been associated to various psychiatric conditions in humans and evokes hippocampus-dependent memory impairments in mice. Despite the extensive studies conducted on hippocampal GAP43 in past decades, however, very little is known about its roles in modulating the excitatory versus inhibitory balance in other brain regions.
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- CRBN is a component of a protein complex linked to regulating neurotransmission, and mutations in its gene lead to a specific type of intellectual disability in humans, which is mimicked in mouse models.
- Research indicates that the overactivation of the cannabinoid CB receptor in these mouse models is likely responsible for observed memory deficits, suggesting a link to reduced excitatory neurotransmission.
- Targeting the CB receptor with specific blockers shows promise in reversing memory issues, which points to a potential therapeutic approach for treating this form of intellectual disability.