Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex.

Background: The insular cortex (IC) plays a pivotal role in processing interoceptive and emotional Information, offering insights into sex differences in behavior and cognition. The IC comprises two distinct subregions: the anterior insular cortex (alC), that processes emotional and social signals, and the posterior insular cortex (pIC), specialized in interoception and perception of pain. Pyramidal projection neurons within the IC integrate multimodal sensory inputs, influencing behavior and cognition.