Publications by authors named "Alayka L Reddy"
Article Synopsis
- Exposure to ultraviolet (UV) light is a known trigger for inflammation in systemic lupus erythematosus (SLE), but the specific cells involved in this response and how UV exposure interacts with interferons are not fully understood.
- This study utilized a murine model of lupus, comparing responses in NZM2328 mice and iNZM mice with a type I interferon receptor knockout, as well as wild-type BALB/c mice, to investigate the effects of different UV treatments.
- Findings showed that myeloid cells, particularly neutrophils and monocyte-derived dendritic cells, play a key role in the inflammatory response to UV exposure in lupus-prone mice, emphasizing the potential for targeting type I interferons and
Cutaneous lupus erythematosus (CLE) is an inflammatory and autoimmune skin condition that affects patients with systemic lupus erythematosus (SLE) and exists as an isolated entity without associated SLE. Flares of CLE, often triggered by exposure to ultraviolet (UV) light result in lost productivity and poor quality of life for patients and can be associated with trigger of systemic inflammation. In the past 10 years, the knowledge of CLE etiopathogenesis has grown, leading to promising targets for better therapies.
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