Two new species of the genus Aeolothrips (Thysanoptera: Aeolothripidae) from Iran.

Two new species Aeolothrips kermanensis sp. n., from the southeast, and Aeolothrips richardi sp.

Naturally occurring T cell mutations enhance engineered T cell therapies.

Adoptive T cell therapies have produced exceptional responses in a subset of patients with cancer. However, therapeutic efficacy can be hindered by poor T cell persistence and function. In human T cell cancers, evolution of the disease positively selects for mutations that improve fitness of T cells in challenging situations analogous to those faced by therapeutic T cells.

Orthogonal cubic splines for the numerical solution of nonlinear parabolic partial differential equations.

In this paper, a new orthogonal basis for the space of cubic splines has been introduced. A linear combination of cubic orthogonal splines is considered to approximate the functions in which the coefficients are calculated with numerically stable formulae. Applications to the numerical solutions of some parabolic partial differential equations are given, in which the approximations are obtained using the first and second integral of orthogonal splines which leads to an efficient solution procedure.

The genus Odontothrips in Iran with two new species (Thysanoptera: Thripidae).

Host-plant associations among the 38 species of Odontothrips Amyot Serville, and features of various structural characters in this genus, are discussed. An illustrated key to 9 species occurring in Iran is provided. Two new species are described from Iran based on specimens on flowers of various Fabaceae.

Modular design of synthetic receptors for programmed gene regulation in cell therapies.

Synthetic biology has established powerful tools to precisely control cell function. Engineering these systems to meet clinical requirements has enormous medical implications. Here, we adopted a clinically driven design process to build receptors for the autonomous control of therapeutic cells.

Kinetic models evaluation for chemical organic matter removal prediction in a full-scale primary facultative pond treating municipal wastewater.

This study focuses on determining the bio-kinetic coefficients of chemical oxygen demand (COD) removal in full-scale primary facultative ponds (PFPs) system on the basis of 3-year continuous operation. The mean removal of chemical oxygen demand (COD), total suspended solid (TSS) and volatile suspended solid (VSS) were 80, 59 and 49%, respectively. The first-order model paired with continuous stirred-tank reactor (CSTR) and plug flow (PF) regimes, PF k-C*, Stover-Kincannon and Grau second-order models were applied to link COD concentrations at the inlet and outlet of the system and to compare the predictive power of models for the estimation of effluent COD concentrations.

Evaluation of the therapeutic regimen in COVID-19 in transplant patients: where do immunomodulatory and antivirals stand?

Background: The management of COVID-19 in organ transplant recipients is among the most imperative, yet less discussed, issues based on their immunocompromised status along with their vast post-transplant medication regimens. No conclusive study has been published to evaluate proper anti-viral and immunomodulator medications effect in treating COVID-19 patients to this date.

Method: This retrospective study was conducted in Shiraz Transplant Hospital, Iran from March 2020 to May 2021 and included COVID-19 diagnosed patients based on SARS-CoV-2 RT-PCR positive test who had been hospitalized for at least 48 h before enrolling in the study.

A new insight for real-time wastewater quality prediction using hybridized kernel-based extreme learning machines with advanced optimization algorithms.

Accurate prediction of inlet chemical oxygen demand (COD) is vital for better planning and management of wastewater treatment plants. The COD values at the inlet follow a complex nonstationary pattern, making its prediction challenging. This study compared the performance of several novel machine learning models developed through hybridizing kernel-based extreme learning machines (KELMs) with intelligent optimization algorithms for the reliable prediction of real-time COD values.

The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition.

Autophagy, a process catabolizing intracellular components to maintain energy homeostasis, impacts aging and metabolism. Spermidine, a natural polyamine and autophagy activator, extends life span across a variety of species, including mice. In addition to protecting cardiac and liver tissue, spermidine also affects adipose tissue through unexplored mechanisms.

SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models.

The first clinically approved engineered chimeric antigen receptor (CAR) T cell therapies are remarkably effective in a subset of hematological malignancies with few therapeutic options. Although these clinical successes have been exciting, CAR T cells have hit roadblocks in solid tumors that include the lack of highly tumor-specific antigens to target, opening up the possibility of life-threatening "on-target/off-tumor" toxicities, and problems with T cell entry into solid tumor and persistent activity in suppressive tumor microenvironments. Here, we improve the specificity and persistent antitumor activity of therapeutic T cells with synthetic Notch (synNotch) CAR circuits.

Cephalothrips (Thysanoptera: Phlaeothripidae) in Iran with two new species and key to species.

The genus Cephalothrips Uzel is a weakly defined genus in subfamily Phlaeothripinae with its members apparently living on various dead tissues and the leaves of live plants. Two species, C. bicolor sp.

Aptinothrips iraniensis sp. n. (Thysanoptera, Thripidae) with a key to the four Aptinothrips species known from Iran.

Aptinothrips iraniensis sp. n. is described from northeast of Iran as the fifth species in this genus.

Polishing low-biodegradable and saline industrial effluent in a full-scale horizontal subsurface flow constructed wetland: evaluation of bio-treatability and predictive power of kinetic models.

This study evaluates the bio-treatability performance and kinetic models of full-scale horizontal subsurface flow constructed wetland used for the tertiary treatment of composite industrial effluent characterized by high-salt content ranging from 5830 to 10,400 µS/cm and biochemical oxygen demand (BOD): chemical oxygen demand (COD) ratio below 0.2. The wetland vegetated with was operated in a semi-arid climate under an average hydraulic loading rate of 63 mm/d.

Biological treatment of slaughterhouse wastewater: kinetic modeling and prediction of effluent.

In this study three modeling approaches consisting Modified Stover-Kincannon, multilayer perceptron neural network (MLPANN) and B-Spline quasi interpolation were applied in order to predict effluent of up-flow anaerobic sludge blanket (UASB) reactor and also to find the reaction kinetics. At first run, the average total chemical oxygen demand (TCOD) removal efficiency was 48.3% with hydraulic retention time (HRT) of 26 h and 63.

Studies on the genus Aeolothrips (Thysanoptera: Aeolothripidae) in Iran, with a key to species.

An illustrated key is provided to 27 species of Aeolothrips Haliday recorded from Iran, including two new species: A. persiae sp. n.

Performance of full-scale coagulation-flocculation/DAF as a pre-treatment technology for biodegradability enhancement of high strength wastepaper-recycling wastewater.

Paper mill wastewater leads to a serious damage on the environment owing to the high content of organic matters, suspended solids, toxic substances, and lignin. Hence, exploring new treatment technologies is the passion of environmental engineers to minimize the effluent impact on the environment and cleaner production aspects. This research focused on the performance of full-scale coagulation-fluctuation/DAF system for pre-treatment of high strength wastepaper-recycling wastewater and its effect on biodegradability improvement.

Anaphothrips sineconus and Hyalopterothrips brunneus, two new species of Anaphothrips genus-group (Thysanoptera) from Iran.

Anaphothrips sineconus sp. n. is described as unique within the genus for the absence from antennal segment III of a sense cone and reduction in some other character states.

Leaf-feeding : two new species from southern Iran (Thysanoptera: Thripidae).

Mycterothrips doostii sp. n. and Mycterothrips zagrosi sp.

One new species and two new records of the genus Aeolothrips from Iran (Insecta, Thysanoptera, Aeolothripidae).

Aeolothrips gundeliae sp. n. is described, and two bicolored species of the same genus, Aeolothrips ericae Bagnall and Aeolothrips albithorax Pelikan are newly reported from northeast of Iran.

The Holarctic genus Aeolothrips (Thysanoptera: Aeolothripidae) from Iran, with description of two new species.

Two new species of the genus Aeolothrips are described from northeast of Iran. A. bhattii sp.

The Iranian Dendrothripinae (Thysanoptera: Thripidae) with description of a new genus and species.

Iranodendrothrips kamalii gen. et sp. n.

Abass Alavi. A distinguished physician scientist and a pioneer in molecular imaging.

Abass Alavi is a world renowned physician-scientist and has made substantial contributions to development and translation of modern imaging techniques to the day-to-day practice of medicine. Among his accomplishments, the introduction of fluorine-18-fluorodeoxyglucose ((18)F-FDG )-positron emission tomography (PET) has truly revolutionized the field of medicine worldwide. The impact of using (18)F-FDG -PET along with computed tomography (CT) (and soon magnetic resonance imaging-MRI) in managing so many serious diseases and disorders is unparalleled by any other technique in recent history.

The genus Mycterothrips (Thysanoptera: Thripidae) in Iran, with three new species.

Three new species of Mycterothripsare described from Khorasane Shomali province in Northeast of Iran, M. mahvelatensis sp.n.

Phase I and pharmacokinetic study of COL-3 in patients with recurrent high-grade gliomas.

COL-3 is a chemically modified tetracycline that targets multiple aspects of matrix metalloproteinase regulation. This phase I clinical trial was conducted to determine the maximum tolerated dose (MTD) of COL-3 in adults with recurrent high-grade glioma, to describe the effects of enzyme-inducing antiseizure drugs (EIADs) on its pharmacokinetics, and to obtain preliminary evidence of activity. Adults with recurrent high-grade glioma were stratified by EIAD use.