[Creatine kinase BB and lactate in the cerebrospinal fluid of neonates and infants with perinatal injuries of the CNS].

A study was made of the content of creatine kinase-BB (CK-BB) and lactate in cerebrospinal fluid (CSF) of 202 neonates and infants with perinatal CNS injuries. The relationship was found between the rise of the CK-BB content and the gravity of perinatal CNS injuries. The highest content of CK-BB in CSF was marked in neonates with cerebral disorders complicated by infectious and inflammatory diseases (pneumonia, sepsis).

[Efficiency and mechanisms of antihypoxic effect of ATP in newborn rats].

Effect of ATP (administered at the doses of 20 mg and 100 mg per kg of body mass) on sensitivity of 5-7 days old rats to acute hypoxia as well as content of 2,3-DPH and ATP in erythrocytes were studied. ATP exhibited the most effective antihypoxic influence at a dose of 100 mg/kg. After administration of ATP a dissimilar increase in content of 2,3-DPH and ATP was observed in erythrocytes of newborn rats maintained under conditions of normal atmospheric pressure.

[Characteristics of the molecular diversities of human and rat aldolase via starch and agar gel electrophoresis].

Content of aldolase isoenzymes was reinvestigated in human and rat tissues by means of agar and starch gel electrophoresis. Heterogeneity of the A type aldolase is established and possible causes of formation of the multiple forms of the enzyme are discussed. The ratio of various fractions of aldolase A was different in erythrocytes of newborn and aldult persons.

[Intracellular distribution of creatine kinase isoenzymes in the brains and hearts of rats at different stages of postnatal development].

The total activity and range of the creatine kinase (CK) isozymes have been studied in the homogenate and subcellular fractions (nuclei, mitochondria, cytoplasm) of the rat brain and heart during postnatal ontogenesis. The total activity of CK in the brain and heart of newborn rats was found to be 4 and 2 times less, resp., than in those of adults.