UK guidelines recommend liraglutide 3.0 mg in adults treated within specialist weight management services with BMI ≥35 kg/m, prediabetes and high cardiovascular disease risk. We aimed to clinically evaluate liraglutide 3.
View Article and Find Full Text PDFUnlabelled: New treatments and increased experience are changing the management of hospitalized coronavirus disease 2019 patients but the impact on ICU management is unclear.
Objectives: To examine characteristics, ventilatory management, and outcomes of critically ill patients in two distinct waves of the pandemic.
Design Setting And Participants: Observational cohort study in an ICU in a single-center university-affiliated U.
Introduction: Cardiovascular diseases (CVDs) are the single greatest contributor to global mortality. The successful introduction and scale-up of antiretroviral therapy (ART) delivered a reduction in HIV mortality. Consequently, an association was found between the scale-up of ART and an increased prevalence of comorbidities among people living with HIV (PLWH) such as hypertension and dyslipidaemia.
View Article and Find Full Text PDFBackground: Type 2 diabetes (T2D) has a reported greater prevalence and poorer treatment outcomes in people living with HIV (PLWH) than comparable HIV-uninfected cohorts. We conducted a cross-sectional study to delineate the factors driving T2D in PLWH in an ethnically diverse cohort, and additionally observed how these have changed over time.
Setting: We studied a diverse HIV cohort in London to determine the prevalence and risk factors for T2D, and compared them to a cohort studied 10 years previously.
Objective: To determine comparative fracture risk in HIV patients compared with uninfected controls.
Design: A randomised cross-sectional study assessing bone mineral density (BMD), fracture history and risk factors in the 2 groups.
Setting: Hospital Outpatients.
Objective: To determine the prevalence and clinical associations of the metabolic syndrome (M-IRS) in an HIV cohort.
Methods And Design: Data was collected prospectively on demographics, anthropometry, HIV disease, drug regimens and cardiometabolic risk factors using a two-centre cross-sectional cohort study design. M-IRS was diagnosed by National Cholesterol Education Program (NCEP) and International Diabetes Federation (IDF) criteria.