Publications by authors named "Alastair Davy"
Article Synopsis
- Therapeutic antibodies utilize their Fc region to connect with immune mechanisms, particularly through binding to complement proteins and Fc receptors, which is vital for their effectiveness.
- Researchers have engineered various Fc region variants of anti-CD20 antibodies and conducted cell-based assays to evaluate their abilities in processes like complement-dependent and antibody-dependent cytotoxicity.
- The study provided insights into how these antibody variants perform differently, suggesting that certain variants may be better suited for specific therapeutic applications due to their unique activities and thermal stability.
Article Synopsis
- Researchers aim to eliminate the binding of immunoglobulin Fc to Fc gamma receptors to prevent unwanted inflammation from therapeutic antibodies and fusion proteins.
- A matched set of anti-CD20 antibodies with various Fc subclasses and variants were created to assess their binding activity to C1q and Fc-gamma receptors, as well as their performance in cell-based assays.
- The findings showed that many variants retained significant activity in at least one assay but often had decreased temperature stability compared to the wild-type antibody.
Article Synopsis
- Melanin is a natural pigment that effectively absorbs energy and has a unique macromolecular structure balancing order and disorder.
- The presence of different ions and variations in pH can significantly affect how melanin forms and its overall structure, even if its absorption properties remain mostly unchanged.
- Understanding these influences could help in manipulating melanin's structure for new bio-engineering applications while maintaining its valuable optical characteristics.
