Publications by authors named "Alanne Rayssa da Silva Melo"
Third-Generation Vaccines: Features of Nucleic Acid Vaccines and Strategies to Improve Their Efficiency.
Genes (Basel)
December 2022
Gene immunization comprises mRNA and DNA vaccines, which stand out due to their simple design, maintenance, and high efficacy. Several studies indicate promising results in preclinical and clinical trials regarding immunization against ebola, human immunodeficiency virus (HIV), influenza, and human papillomavirus (HPV). The efficiency of nucleic acid vaccines has been highlighted in the fight against COVID-19 with unprecedented approval of their use in humans.
View Article and Find Full Text PDFThe current pandemic called COVID-19 caused by the SARS-CoV-2 virus brought the need for the search for fast alternatives to both control and fight the SARS-CoV-2 infection. Therefore, a race for a vaccine against COVID-19 took place, and some vaccines have been approved for emergency use in several countries in a record time. Ongoing prophylactic research has sought faster, safer, and precise alternatives by redirecting knowledge of other vaccines, and/or the development of new strategies using available tools, mainly in the areas of genomics and bioinformatics.
View Article and Find Full Text PDFSARS-CoV, MERS-CoV and SARS-CoV-2 infections in pregnancy and fetal development.
J Gynecol Obstet Hum Reprod
June 2020
Recently, in China, in 2019, a new type of disease has arisen caused by a new strain of coronavirus, the SARS-CoV-2 virus, considered extremely worrying due to its high infectivity power and the easy ability to spread geographically. For patients in general, the clinical features resulting from respiratory syndromes can trigger an asymptomatic condition. However, 25 % of patients infected by SARS-CoV-2 can progress to severity.
View Article and Find Full Text PDFArticle Synopsis
- Cervical cancer and cervical intraepithelial neoplasia (CIN) are often caused by human papillomavirus (HPV) infections, particularly involving oncogenes like E6, E7, and E5 which drive malignant progression.
- While effective HPV vaccines exist, treatments for existing cervical neoplasia are limited, and late diagnosis leads to poorer outcomes; conventional methods like surgery and chemotherapy are often ineffective for high-grade lesions.
- Emerging genetic immunotherapy, particularly DNA vaccines targeting HPV, show promise in clinical trials and suggest a potential for improved treatment through combination approaches involving these vaccines along with other therapies like radiotherapy and immuno-modulators.
Background: epigenomes can be influenced by environmental factors leading to the development of diseases.
Objective: To investigate the influence of sun exposure on global DNA methylation and hydroxymethylation status and at specific sites of the miR-9-1, miR-9-3 and MTHFR genes in skin samples of subjects with no history of skin diseases.
Methods: Skin samples were obtained by punch on sun-exposed and sun-protected arm areas from 24 corpses of 16-89 years of age.
Background: Studies have shown that a variety of environmental factors and habits are associated with epigenetic changes. In addition, various genes are also found to respond to UV radiation.
Objectives: The aim of this study was to investigate the sun exposure influence on the DNA methylation profile on the matrix metalloprotease-9 (MMP9), microRNA 137 (miR-137), cytokeratin 14 (KRT14) and 19 (KRT19) genes of skin cells of subjects with no history of skin diseases.