Predicting circadian phase across populations: a comparison of mathematical models and wearable devices.

From smart work scheduling to optimal drug timing, there is enormous potential in translating circadian rhythms research results for precision medicine in the real world. However, the pursuit of such effort requires the ability to accurately estimate circadian phase outside of the laboratory. One approach is to predict circadian phase noninvasively using light and activity measurements and mathematical models of the human circadian clock.

Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study.

In addition to the caloric and macronutrient composition of meals, timing of energy consumption may be important for optimal glucose metabolism. Our goal was to examine whether the habitual timing of energy intake was associated with insulin sensitivity in healthy volunteers. Volunteers without diabetes aged 21-50 years completed a 3-day food diary and underwent an oral glucose tolerance test to estimate insulin sensitivity ( = 44).

Glycation of human cortical and cancellous bone captures differences in the formation of Maillard reaction products between glucose and ribose.

To better understand some aspects of bone matrix glycation, we used an in vitro glycation approach. Within two weeks, our glycation procedures led to the formation of advanced glycation end products (AGEs) at the levels that corresponded to approx. 25-30 years of the natural in vivo glycation.