Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy" blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study.

Cancer is the leading cause of death in dogs, yet there are no established screening paradigms for early detection. Liquid biopsy methods that interrogate cancer-derived genomic alterations in cell-free DNA in blood are being adopted for multi-cancer early detection in human medicine and are now available for veterinary use. The CANcer Detection in Dogs (CANDiD) study is an international, multi-center clinical study designed to validate the performance of a novel multi-cancer early detection "liquid biopsy" test developed for noninvasive detection and characterization of cancer in dogs using next-generation sequencing (NGS) of blood-derived DNA; study results are reported here.

Rabbit Soft Tissue Surgery.

This article summarizes the available information on different soft tissue surgical procedures in rabbits, based on the literature and the authors' experiences, emphasizing the differences between rabbits and the more familiar dogs and cats. The major surgical principles in rabbits are discussed, and common surgical procedures, such as abdominal exploration, gastrotomy, enterotomy, liver lobectomy, nephrectomy, cystotomy, cystectomy, ovariohysterectomy, ovariectomy, orchidectomy, are described.

Evaluation of a porcine vascular model to assess the efficacy of various hemostatic techniques.

Background: A novel live porcine model replicated the endoscopic surgical field of a carotid arterial injury of the human skull base. Hemostatic techniques were applied to jugular venous and carotid arterial injuries, including muscle patches, hemoclips, and aneurysm clips. Doppler imaging distal to the injury assessed flow through the repaired vessel.

Use of pleural access ports for treatment of recurrent pneumothorax in two dogs.

Case Description: An 8-year-old castrated male mixed-breed dog (dog 1) and a 13-year-old spayed female mixed-breed dog (dog 2) were evaluated because of spontaneous pneumothorax.

Clinical Findings: Both dogs had decreased bronchovesicular sounds with coughing, tachypnea, cyanosis, lethargy, or a combination of these clinical signs. Radiographic examination revealed pneumothorax in both dogs and consolidation of a lung lobe in dog 2.

Use of vascular access ports in femoral veins of dogs and cats with cancer.

Objective: To evaluate long-term function of vascular access ports (VAPs) implanted in the femoral vein of dogs and cats undergoing cancer treatment.

Design: Prospective clinical study.

Animals: 3 dogs and 6 cats treated via chemotherapy or radiation.

Prognostic factors for survival of dogs with inguinal and perineal mast cell tumors treated surgically with or without adjunctive treatment: 68 cases (1994-2002).

Objective: To determine the prognostic factors for survival and tumor recurrence in dogs with cutaneous mast cell tumors (MCTs) in the perineal and inguinal regions treated surgically with or without adjunctive radiation therapy, chemotherapy, or both.

Design: Retrospective study.

Animals: 68 dogs.