Developmental trajectories for young children with 16p11.2 copy number variation.

Copy number variation at 16p11.2 is associated with diverse phenotypes but little is known about the early developmental trajectories and emergence of the phenotype. This longitudinal study followed 56 children with the 16p11.

A comparison of hip joint centre localisation techniques with 3-DUS for clinical gait analysis in children with cerebral palsy.

Functional calibration techniques have been proposed as an alternative to regression equations for estimating the position of the hip within the pelvic co-ordinate system for clinical gait analysis. So far validation of such techniques has focussed on healthy adults. This study evaluated a range of techniques based on regression equations or functional calibration procedures techniques in 46 children representative of those attending a major clinical gait analysis service against previously validated 3-D ultrasound techniques for determining the hip joint centre.

Hip joint centre localization: Evaluation on normal subjects in the context of gait analysis.

Locating the position of the hip joint centre (HJC) is an important part of lower limb modeling for gait analysis. Regression equations have been used in the past but a range of functional calibration methods are now available. This study compared the accuracy of HJC localization from two sets of regression equations and five different functional calibration methods against three dimensional ultrasound (3-DUS) on a population of 19 able bodied subjects.

Validation of 3-D freehand ultrasound for the determination of the hip joint centre.

This paper describes the calibration process for 3-D free hand ultrasound (3-DUS). The Cambridge calibration technique was determined to produce the most repeatable and accurate results when determining the location of a reference object within a water bath. This note additionally validates 3-DUS as a potential measurement tool for the determination of the hip joint centre.

Quantification of soft tissue artifact in lower limb human motion analysis: a systematic review.

This systematic review critically evaluates the quantification of soft tissue artifact (STA) in lower limb human motion analysis. It has a specific focus on assessing the quality of previous studies and comparing quantitative results. A specific search strategy identified 20 published articles or abstracts that fulfilled the selection criteria.

Obstacle crossing deficits in older adults: a systematic review.

This systematic review and critical evaluation of the literature investigates whether advanced age compromises obstacle crossing for unconstrained and time-constrained conditions. Eight electronic databases were searched for articles with terms relating to obstacle crossing during walking in their title, abstract or keywords. 15 articles were reviewed from an initial yield of 727 articles.

Determination of the optimal locations of surface-mounted markers on the tibial segment.

This study aims to determine optimal locations on the lower limbs for skin-mounted markers representing the tibial segment in three-dimensional (3D) gait analysis. It was predicted that markers located on the anterior tibial crest and malleoli would be least susceptible to soft tissue movement. Ten retro-reflective markers were attached to each tibial segment for 20 participants.