Publications by authors named "Alan Y Chen"
Ann Clin Transl Neurol
December 2024
Article Synopsis
- The study investigates how the monoclonal antibody lecanemab, used for treating Alzheimer's by targeting amyloid beta, interacts with plasma proteins, particularly focusing on its relatively short half-life due to these interactions.
- * Researchers employed techniques like ELISA and western blotting to analyze the binding of a lecanemab biosimilar to plasma proteins, identifying fibrinogen as a potential binding partner.
- * The findings suggest that fibrinogen levels could affect the availability of lecanemab in the bloodstream, highlighting the importance of considering plasma protein binding in the clinical use of therapeutic antibodies for neurodegenerative diseases.
