Publications by authors named "Alan Tardin da Silva"
Maternal 5CpG Imprints at the and Differentially Methylated Regions Are Decoupled From Parent-of-Origin Expression Effects in Multiple Human Tissues.
Graziela de Sá Machado Araújo Ronaldo da Silva Francisco Junior Cristina Dos Santos Ferreira Pedro Thyago Mozer Rodrigues Douglas Terra Machado Cleiton Figueiredo Osorio da Silva Antônio Francisco Alves da Silva Alan Tardin da Silva
Front Genet
March 2018
Article Synopsis
- The study focuses on understanding how certain genes in mammals are regulated by differences in DNA methylation based on whether the gene is inherited from the mother or father, which leads to the creation of imprinted differentially methylated regions (iDMRs).
- Researchers identified 125 new candidate iDMRs that show patterns of methylation differing between parental alleles, particularly noting that some of these iDMRs are associated with specific tissues or developmental stages, influencing whether genes are turned on or off.
- Using RNA-Seq data, the study reveals that some genes' expressions near iDMRs can be regulated differently based on tissue type, suggesting that these distant iDMRs play a role in controlling how