Synthesis, cytotoxicity, and QSAR analysis of X-thiophenols in rapidly dividing cells.

In this study, the cytotoxicities of a series of X-thiophenols vs rapidly growing mouse leukemia cells in vitro are determined. The resulting ID(50) values are then used to formulate a quantitative structure-activity relationship, which is well-correlated by the Brown variation of the Hammett electronic parameter, sigma-plus (sigma(+) ), such that Log 1/ID(50) = -0.93 (+/-0.