Publications by authors named "Alan S Ryan"

Background: Hyperoxaluria is typically associated with excessive oxalate intake in the diet, decreased dietary calcium, hyperabsorption of oxalate, or increased endogenous production of oxalate. The disorder spectrum extends from recurrent kidney stones to ESKD. This clinical trial sought to evaluate the effectiveness of an acid stable oxalate decarboxylase (OxDC) to reduce urinary oxalate in healthy subjects on a high-oxalate diet.

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Considerable advances have been made in the field of infant feeding research. The last few decades have witnessed the expansion in the number of studies on the composition and benefits of human milk. The practice of breastfeeding and use of human milk represent today's reference standards for infant feeding and nutrition.

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Arachidonic acid (ARA, 20:4n-6) is an n-6 polyunsaturated 20-carbon fatty acid formed by the biosynthesis from linoleic acid (LA, 18:2n-6). This review considers the essential role that ARA plays in infant development. ARA is always present in human milk at a relatively fixed level and is accumulated in tissues throughout the body where it serves several important functions.

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Article Synopsis
  • Docosahexaenoic acid (DHA) is linked to brain health, with lower levels associated with cognitive decline, especially in older adults and Alzheimer's patients.
  • A study involved 485 healthy older adults taking either 900 mg of DHA or a placebo for 24 weeks, focusing on their cognitive functions, specifically memory and learning.
  • Results showed that DHA significantly improved memory performance and learning abilities compared to the placebo, with participants experiencing no serious side effects.
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Omega-3 and omega-6 long-chain polyunsaturated fatty acids (LCPUFA) are critical for infant and childhood brain development, but levels of the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are often low in the Western diet. Increasing evidence from both epidemiological and intervention studies, reviewed here, indicates that DHA supplementation, during pregnancy, lactation, or childhood plays an important role in childhood neurodevelopment. Arachidonic acid (ARA) is also important for infant growth and development.

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Preclinical and clinical studies demonstrate that the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) as a triacylglycerol (TAG) or an ethyl ester are protective against cardiovascular disease. Both have significant TAG-lowering effects. We developed a concentrated ethyl ester of DHA (MATK-90, 900 mg/g) using microalgae as its source.

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The cardiovascular benefits of fish-derived long-chain polyunsaturated fatty acids, docosahexaenoic acid (DHA), and eicosapentaenoic acid are well established. Less studied are specific effects of individual long-chain polyunsaturated fatty acids. Based on data from 16 published clinical trials, this review examines effects of DHA triglyceride (TG) oil derived from algae (algal-DHA) on serum TG levels and related parameters.

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The utility of multicenter cognitive test methodology and resultant outcomes of supplementation with docosahexaenoic acid in healthy 4-year-old children was evaluated in a randomized, placebo-controlled, double-blind study. Subjects received 400-mg/d docosahexaenoic acid (n = 85) or matching placebo (n = 90) in capsules for 4 months. Cognitive tests included the Leiter-R Test of Sustained Attention, Peabody Picture Vocabulary Test, Day-Night Stroop Test, and Conners' Kiddie Continuous Performance Test.

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An assay involving a finger stick and filter paper blood spotting was developed to determine polyunsaturated fatty acid (PUFA) levels in blood. Capillary whole blood from a finger stick was blotted on antioxidant impregnated filter paper, air dried, saponified and methylated using sodium hydroxide and boron trifluoride in methanol. The method differed from those described previously because separation of plasma and red blood cells (RBCs) was not needed, thin-layer chromatography (TLC) was not required to separate phospholipids, initial extraction of lipids before transesterification was not necessary, and the fatty acid methyl ester (FAME) method was able to methylate steryl esters, free fatty acids, and sphingomyelins.

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Breastfeeding is suggested to be a potential obesity prevention strategy, but the evidence that breast-fed infants have a lower risk of later obesity is equivocal. Fourteen studies published between 2003 and 2006 that considered the relationship between breastfeeding and risk of childhood overweight and obesity were reviewed. Three studies reported a protective effect in children (i.

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Background: In the United States, more new mothers are part of the work force than ever before. This trend has implications for many child-rearing practices, including breastfeeding.

Methods: Based on a national sample of new mothers (n = 228,000), this study considered the prevalence of the initiation and duration of breastfeeding to 6 months after delivery in 2003 among women who were employed full time, who worked part time, or who were not employed outside the home.

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Objective: We set out to compare rates of breastfeeding between women who participated in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) with those of non-WIC mothers from 1978 to 2003.

Methods: The Ross Laboratories Mothers Survey is a national survey designed to determine patterns of milk feeding during infancy. Mothers were asked to recall the type of milk fed to their infant in the hospital and during each month of age.

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Background: Poor growth has been described in patients with urea cycle enzyme defects treated with protein-restricted diets, while protein status is seldom reported.

Objective: To assess the effects of nutritional therapy with a medical food on growth and protein status of patients with a urea cycle enzyme defect.

Methods: A 6-mo multicenter outpatient study was conducted with infants and toddlers managed by nutrition therapy with Cyclinex-1 Amino Acid-Modified Medical Food with Iron (Ross Products Division, Abbott Laboratories, Columbus, OH).

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With use of data from the Ross Mothers Survey (RMS), rates for breastfeeding in the hospital and at 6 months of age were evaluated within 4 geographical regions of the United States. Odds ratios for determinants of breastfeeding were also calculated. Regardless of sociodemographic characteristics, breastfeeding in the hospital and at 6 months of age was most common in the West and least common in the South.

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Objective: To update reported rates of breastfeeding and exclusive breastfeeding through 2001 and to compare rates in 2001 to those from 1996.

Methods: The Ross Laboratories Mothers Survey (RLMS) is a large, national survey designed to determine patterns of milk feeding during infancy. Questionnaires were mailed each month to a representative sample of mothers when their infant was 1 month of age, 2 months of age, 3 months or age, and so forth.

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Objective: To provide clinically meaningful, normative reference data that describe the timing of sexual maturity indicators among a national sample of US children and to determine the degree of racial/ethnic differences in these estimates for each maturity indicator.

Methods: Tanner staging assessment of sexual maturity indicators was recorded from 4263 non-Hispanic white, black, and Mexican American girls and boys aged 8.00 to 19.

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Selected age- and sex-specific percentiles are presented for 4,054 Mexican American children ages 1-18 years who were included in the third National Health and Nutrition Examination Survey (NHANES III, 1988-1994). These percentile values are compared with corresponding percentiles for Mexican Americans from the Hispanic Health and Nutrition Examination Survey (HHANES, 1982-1984). In each sex, the weight and weight/stature(2) percentiles from NHANES III were significantly larger than those from HHANES.

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Between May 1993, and September 1994, a randomized, blinded clinical trial was conducted to evaluate measures of growth and body composition in 63 (32 males; 31 females) healthy, low-birth-weight infants (940-2250 g) who were randomly assigned to an infant formula with docosahexaenoic acid (22:6n3, DHA, 0.2 wt%) from fish oil or to a control formula. A preterm formula with or without DHA was fed beginning at 7-10 days prior to hospital discharge through 43 weeks postmenstrual age (PMA).

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Data for arm muscle area (AMA) and arm adipose tissue area (AATA) from 3695 Mexican American children 6 months to 18 years of age included in HHANES (1982-1984) were used to obtain age-and gender-specific means and selected percentiles. These statistics were compared with those for non-Hispanic white and non-Hispanic black children from NHANES II (1976-1980). In comparison with non-Hispanic white and non-Hispanic black children, the Mexican American children tended to have smaller means and percentile values for AMA but larger values for AATA.

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This study presents descriptive statistics for head circumference in Mexican American children 6 months to 7 years of age using data from the Hispanic Health and Nutrition Examination Survey (HHANES, 1982-1984) and compares these statistics with national estimates of head circumference for non-Hispanic White children and non-Hispanic Black children from the Second National Health and Nutrition Examination Survey (NHANES II, 1976-1980). Head circumference was measured in the same standardized fashion in the two surveys. The patterns of change with age in means and in empirical percentiles were similar for both genders and for all three ethnic groups.

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The second National Health and Nutrition Examination Survey (NHANES II) 1976-1980 provided detailed information concerning the dietary patterns of older Americans. By using 24-hour dietary recall and food frequency questionnaires, the dietary patterns of 2,615 adults aged 65-74 years were evaluated by types of living arrangements (living alone, with a spouse, or with someone other than a spouse) and income level (below poverty, at or above poverty). Analyzed indicators of dietary quality were caloric and nutrient intake, food group intake and frequency, and number of meals skipped.

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